Étiquette : neuroadaptation

Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction, Guichang Zou et al., 2020

Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction Guichang Zou, Xin Zuo, Kai Chen, ..., Guangming Huang, Dan Liu, Wei Xiong Cell Reports, 2020, 30, 4209–4219 Doi : 10.1016/j.celrep.2020.02.106   In Brief Zou et al. identify the glycine receptor as a potential therapeutic target for cannabinoids in treating cocaine-induced seizures. The function of extra-synaptic glycine receptors in the prefrontal cortex and hippocampus is impaired by cocaine and rescued by cannabinoids, therefore leading to the therapeutic effects of cannabinoids in treating cocaine-induced seizures. Highlights Cannabinoids alleviate cocaine-induced seizures (CISs) by glycine receptors (GlyRs) Cannabinoid docking reduces hydrogen-bonding interaction between cocaine and GlyRs The prefrontal cortex and hippocampus [...]

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Neurocognitive Consequences of Chronic CannabisUse : A Systematic Review and Meta-Analysis, Pedro Rafael Figueiredo et al., 2019

Neurocognitive Consequences of Chronic CannabisUse : A Systematic Review and Meta-Analysis Pedro Rafael Figueiredo, Serenella Tolomeo, J. Douglas Steele, Alexander Baldacchino Neuroscience and Biobehavioral Reviews, 2019 Doi : 10.1016/j.neubiorev.2019.10.014   "Une méta-analyse échoue à mettre en évidence une "toxicité" de l'usage du cannabis à long terme, sur les fonctions neuropsychologiques cognitives"   Highlights  A meta-analysis was conducted to assess the neuropsychological impact of cannabis.  A limited association was found between chronic cannabis use and neurocognitive deficits.  Memory and chronic cannabis smoking were linked. ABSTRACT Cannabis is currently the most used illicit substance in the world with a global widespread distribution. Although its acute neurocognitive effects on human behaviour have [...]

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Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone, Roberto Frau et al., 2019

Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone Roberto Frau, Vivien Miczán, Francesco Traccis, Sonia Aroni, Csaba I. Pongor, Pierluigi Saba, Valeria Serra, Claudia Sagheddu, Silvia Fanni, Mauro Congiu, Paola Devoto, Joseph F. Cheer, István Katona and Miriam Melis Nature Neuroscience,  December 2019, VOL 22, 1975–1985 www.nature.com/natureneuroscience1975 Content courtesy of Springer Nature, terms of use apply. Rights reserved Doi : 10.1038/s41593-019-0512-2 The increased legal availability of cannabis has led to a common misconception that it is a safe natural remedy for, among others, pregnancy-related ailments such as morning sickness. Emerging clinical evidence, however, indicates that prenatal cannabis exposure (PCE) predisposes offspring to various neuropsychiatric [...]

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Neuroanatomical alterations in people with high and low cannabis dependence, Valentina Lorenzetti et al., 2019

Neuroanatomical alterations in people with high and low cannabis dependence Valentina Lorenzetti, Yann Chye, Chao Suo, Mark Walterfang, Dan I Lubman, Michael Takagi, Sarah Whittle, Antonio Verdejo-Garcia, Janna Cousijn, Christos Pantelis, Marc Seal, Alex Fornito, Murat Yücel and Nadia Solowij Australian & New Zealand Journal of Psychiatry, 2019, 1–8 https://doi.org/10.1177/0004867419859077   Abstract Objectives : We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regions of the stress and reward brain circuits. Methods : To examine dependence-specific regional brain alterations, we compared the volumes of regions relevant to reward and stress, between high-dependence cannabis users (CD+, n = 25), low [...]

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