Étiquette : maternal choline

Interaction of maternal choline levels and prenatal Marijuana’s effects on the offspring, Camille Hoffman et al., 2019

Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring Camille Hoffman, Sharon K. Hunter, Angelo D'Alessandro, KathleenNoonan et al. Psychological Medicine, 2019 Doi : https://doi.org/10.1017/S003329171900179X Published online by Cambridge University Press: 31 July 2019 Abstract Background : This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from the mother activates α7-nicotinic acetylcholine receptors on fetal cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade of their cannabinoid-1(CB1) receptors. Methods : Marijuana use was assessed during pregnancy from women who later brought their newborns for study. Mothers were informed about [...]

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