Étiquette : enfants

Medical cannabis for severe treatment resistant epilepsy in children : a case-series of 10 patients, Rayyan Zafar, David Nutt et al., 2021

Medical cannabis for severe treatment resistant epilepsy in children : a case-series of 10 patients Rayyan Zafar, Anne Schlag, Lawrence Phillips, David J Nutt BMJ Paediatrics Open, 2021, 5, e001234. doi : 10.1136/bmjpo-2021-001234 ABSTRACT Objectives : To report the findings of a case-series of 10 children suffering with intractable epilepsies in the UK to determine the feasibility for using whole-plant cannabis medicines to treat seizures in children. Setting : This study was conducted retrospectively through collecting clinical data from caretakers and clinicians on study outcome variables. Participants were recruited through the MedCann Support and End our Pain charity groups which are patient representative groups that support children [...]

Lire la suite

Whole-plant Cannabis Linked to Large Reduction in Seizures Kelli Whitlock Burton, Medscape, 2021.

Whole-plant Cannabis Linked to Large Reduction in Seizures Kelli Whitlock Burton Medscape - Dec 29, 2021. https://www.medscape.com/viewarticle/965756   Whole-plant cannabis is linked to a significant reduction in seizures in children with severe treatment-resistant epilepsy, early research suggests. In a small case series, children with severe treatment-resistant epilepsy treated with a range of whole-plant extract cannabis-based medical products (CBMPs) reported an 86% reduction in monthly seizures. All participants had no improvement with traditional antiepileptic drugs (AEDs). The study adds to a small but growing body of research investigating whole-plant cannabis medicines containing tetrahydrocannabinol (THC) in pediatric epilepsies. Rayyan Raja Zafar "Although we have previously noted the superior efficacy of whole-plant medical cannabis is a previous [...]

Lire la suite

Epidiolex Plus THC May Lower Seizures in Pediatric Epilepsy Randy Dotinga, Medscape.com, 2021.

Epidiolex Plus THC May Lower Seizures in Pediatric Epilepsy Randy Dotinga  Medscape.com - Oct 14, 2021. https://www.medscape.com/viewarticle/960842   Children and young adults with epilepsy had fewer seizures after combination treatment with the drug Epidiolex, which contains the cannabidiol (CBD), and various doses of tetrahydrocannabinol (THC), the component of cannabis that makes people high in larger quantities, researchers reported. "THC can contribute to seizure control and mitigation some of the side effects of CBD," said study coauthor and Austin, Tex., child neurologist Karen Keough, MD, in an interview. Keough and colleagues presented their findings at the 50th annual meeting of the Child Neurology Society. In a landmark move, the Food and [...]

Lire la suite

Data Supporting Cannabis for Childhood Epilepsy Remain Scarce, Will Pass, Medscape.com,  2021

Data Supporting Cannabis for Childhood Epilepsy Remain Scarce Will Pass Medscape.com, September 13, 2021 https://www.medscape.com/viewarticle/958616   Cannabis-based medicinal products (CBMPs) have shown early promise for refractory childhood epilepsy, but positive media attention, as well as pressure from politicians and marijuana advocacy groups, should not supplant clinical trials and acceptable standards of evidence, according to two leading experts. In a recent invited review article, Martin Kirkpatrick, MD, of the University of Dundee (Scotland), and Finbar O'Callaghan, MD, PhD, of University College London suggested that childhood epilepsy may be easy terrain for commercial interests to break ground, and from there, build their presence. "Children with epilepsy are at risk of being [...]

Lire la suite

Cannabis-related diagnosis in pregnancy and adverse maternal and infant outcomes, Gretchen Bandoli et al., 2021

Cannabis-related diagnosis in pregnancy and adverse maternal and infant outcomes Gretchen Bandoli, Laura Jelliffe-Pawlowski, Benjamin Schumacher, Rebecca J. Baer, Jennifer N. Felder, Jonathan D. Fuchs, Scott P. Oltman, Martina A. Steurer, Carla Marienfeld Drug and Alcohol Dependence, 2021, 225, 108757. doi : 10.1016/j.drugalcdep.2021.108757   Abstract Background: Cannabis use and cannabis use disorders are increasing in prevalence, including among pregnant women. The objective was to evaluate the association of a cannabis-related diagnosis (CRD) in pregnancy and adverse maternal and infant outcomes. Methods: We queried an administrative birth cohort of singleton deliveries in California between 2011-2017 linked to maternal and infant hospital discharge records. We [...]

Lire la suite

Does cannabidiol reduce severe behavioural problems in children with intellectual disability? Study protocol for a pilot single-site phase I/II randomised placebo controlled trial, Daryl Efron et al.,

Does cannabidiol reduce severe behavioural problems in children with intellectual disability? Study protocol for a pilot single-site phase I/II randomised placebo controlled trial Daryl Efron, Kaitlyn Taylor, Jonathan M Payne, Jeremy L Freeman, Noel Cranswick, Melissa Mulraney, Chidambaram Prakash, Katherine J Lee, Katrina Williams BMJ Open, 2020, 10, e034362. doi : 10.1136/bmjopen-2019-034362   Abstract Introduction : Severe behavioural problems (SBPs) are a common contributor to morbidity and reduced quality of life in children with intellectual disability (ID). Current medication treatment for SBP is associated with a high risk of side effects. Innovative and safe interventions are urgently needed. Anecdotal reports and preliminary research suggest that medicinal [...]

Lire la suite

A Pilot Randomised Placebo-Controlled Trial of Cannabidiol to Reduce Severe Behavioural Problems in Children and Adolescents With Intellectual Disability, Daryl Efron et al., 2020

  A Pilot Randomised Placebo-Controlled Trial of Cannabidiol to Reduce Severe Behavioural Problems in Children and Adolescents With Intellectual Disability Daryl Efron, Jeremy L Freeman, Noel Cranswick, Jonathan M Payne, Melissa Mulraney, Chidambaram Prakash, Katherine J Lee, Kaitlyn Taylor, Katrina Williams British Journal of Clinical Pharmacology, 2020 Jun 1. doi : 10.1111/bcp.14399. Abstract Introduction : Severe Behavioural Problems (SBP) are a major contributor to morbidity in children with Intellectual Disability (ID). Medications used to treat SBP in ID are associated with a high risk of side effects. Cannabidiol has potential therapeutic effects in SBP. This pilot study aimed to investigate the feasibility of conducting a randomized placebo-controlled [...]

Lire la suite

Dissiper la fumée entourant le cannabis : Effets du cannabis pendant la grossesse – version actualisée, CCDUS, Amy J. Porath et al., 2018

Dissiper la fumée entourant le cannabis : Effets du cannabis pendant la grossesse – version actualisée Amy J. Porath, Ph.D., Directrice, Recherche, CCDUS Sarah Konefal, Ph.D., Analyste, Recherche et politiques, CCDUS Pam Kent, Ph.D., Directrice associée, Recherche, CCDUS Centre Canadien sur les dépendances et l'usage de substances, 2018   Le présent rapport est le deuxième d’une série sur les effets du cannabis sur divers aspects du fonctionnement et du développement de la personne. Révision d’un rapport précédent, il aborde les effets sur l’enfant et les jeunes adultes de la consommation de cannabis pendant la grossesse et fait état des nouvelles recherches qui valident et approfondissent nos connaissances sur [...]

Lire la suite

Cannabis for pediatric epilepsy : protocol for a living systematic review, Jesse Elliott et al., 2018

Cannabis for pediatric epilepsy : protocol for a living systematic review Jesse Elliott, Deirdre DeJean, Tammy Clifford, Doug Coyle, Beth Potter, Becky Skidmore, Christine Alexander, Alexander E. Repetski, Bláthnaid McCoy and George A. Wells Systematic Reviews, 2018, 7, 95 doi : 10.1186/s13643-018-0761-2   Abstract Background : Pediatric epilepsy, including treatment-resistant forms, has a major effect on the quality of life, morbidity, and mortality of affected children. Interest has been growing in the use of medical cannabis as a treatment for pediatric epilepsy, yet there has been no comprehensive review of the benefits and harms of cannabis use in this population. In this systematic review, we will [...]

Lire la suite