Étiquette : dépendance

CANNABIDIOL (CBD), Pre-Review Report, Agenda Item 5.2, Expert Committee on Drug Dependence, WHO, 2017

CANNABIDIOL (CBD), Pre-Review Report, Agenda Item 5.2 Expert Committee on Drug Dependence Thirty-ninth Meeting, Geneva, 6-10 November 2017 39th ECDD (2017) Agenda item 5.2 Cannabidiol (CBD) Contents Acknowledgements .................................................................................................................. 4 Summary ................................................................................................................................... 5 1. Substance identification ........................................................................................................ 6 A. International Nonproprietary Name (INN) .......................................................................... 6 B. Chemical Abstract Service (CAS) Registry Number .............................................................. 6 C. Other Chemical Names .......................................................................................................... 6 D. Trade Names .......................................................................................................................... 6 E. Street Names .......................................................................................................................... 6 F. Physical Appearance .............................................................................................................. 6 G. WHO Review History ............................................................................................................. 6 2. Chemistry ............................................................................................................................... 6 A. Chemical Name ...................................................................................................................... 6 B. Chemical Structure ................................................................................................................. 7 C. Stereoisomers ......................................................................................................................... 7 D. Methods and Ease of Illicit Manufacturing ............................................................................ 7 E. Chemical Properties ............................................................................................................... 9 F. Identification and Analysis ..................................................................................................... 9 3. Ease of [...]

Lire la suite

Assessment of the Psychotherapeutic Effects of Ritual Ayahuasca Use on Drug Dependency : A Pilot Study, Xavier Fernández et al., 2014

Assessment of the Psychotherapeutic Effects of Ritual Ayahuasca Use on Drug Dependency : A Pilot Study Xavier Fernández, Rafael Guimarães dos Santos, Marta Cutchet, Sabela Fondevila, Débora González, Miguel Ángel Alcázar, Jordi Riba, José Carlos Bouso, Josep María Fábregas, Xavier Fernández, Rafael Guimarães dos Santos in "The Therapeutic Use of Ayahuasca", Chapter 11, 183-196 Beatriz Caiuby LABATE, Clancy CAVNAR Editors, Springer-Verlag, Berlin, Heidelberg, 2014 First Online: 23 November 2013 Abstract Using personality, psychopathology, and neuropsychological assessment instruments, our team assessed the therapeutic effects of an ayahuasca ritual treatment. Data was collected at the Institute of Applied Amazonian Ethnopsychology (IDEAA), in the Brazilian Amazon Basin. Psychological assessments [...]

Lire la suite

Clinical potential of psilocybine as a treatment for mental health conditions, Jeremy Daniel & Margaret Haberman, 2017.

Clinical potential of psilocybine as a treatment for mental health conditions Jeremy Daniel & Margaret Haberman Mental Health Clinician, 2017, Vol. 7, No. 1, pp. 24-28 https://doi.org/10.9740/mhc.2017.01.024   Abstract Psilocybin, a classic hallucinogen, is a chemical produced by more than 100 species of mushrooms worldwide. It has high affinity for several serotonin receptors, including 5-HT1A, 5-HT2A, and 5-HT2C, located in numerous areas of the brain, including the cerebral cortex and thalamus. With legislation introduced in 1992, more work is being done to further understand the implications of psilocybin use in a number of disease states. Certain mental health disease states and symptoms have been studied, including [...]

Lire la suite

Cannabis use, dependence and withdrawal in indigenous male inmates, Bernadette Rogerson et al., 2014

Cannabis use, dependence and withdrawal in indigenous male inmates Bernadette Rogerson, Susan P. Jacups, and Nerina Caltabiano Journal of  Substance Use, 2014, 1–7 DOI: 10.3109/14659891.2014.950702 ISSN: 1465-9891 (print), 1475-9942 (electronic) Abstract Background : No studies have investigated cannabis withdrawal in indigenous or incarcerated populations, and there is currently no standard treatment for cannabis withdrawal in Australian prisons. Aims : This cross sectional survey examines cannabis use, dependence and involuntary (abrupt cessation) withdrawal in incarcerated indigenous males for the purpose of improving clinical management. Methods : 101 consenting inmates (18–40 years) from an Australian correction centre were interviewed. Demographic characteristics, lifetime cannabis use (LCU), severity of dependence, cannabis withdrawal [...]

Lire la suite

The Potential of Cannabidiol as a Treatment for Psychosis and Addiction : Who Benefits Most ? A Systematic Review, Albert Batalla et al., 2019

The Potential of Cannabidiol as a Treatment for Psychosis and Addiction : Who Benefits Most ? A Systematic Review Albert Batalla, Hella Janssen, Shiral S. Gangadin and Matthijs G. Bossong Journal of Clinical Medicine, 2019, 8, 1058 doi : 10.3390/jcm8071058 Abstract : The endogenous cannabinoid (eCB) system plays an important role in the pathophysiology of both psychotic disorders and substance use disorders (SUDs). The non-psychoactive cannabinoid compound, cannabidiol (CBD) is a highly promising tool in the treatment of both disorders. Here we review human clinical studies that investigated the ecacy of CBD treatment for schizophrenia, substance use disorders, and their comorbidity. In particular, we examined [...]

Lire la suite

Nabiximols combined with motivational enhancement/cognitive behavioral therapy for the treatment of cannabis dependence : A pilot randomized clinical trial, Jose M. Trigo et al., 2018

Nabiximols combined with motivational enhancement/cognitive behavioral therapy for the treatment of cannabis dependence : A pilot randomized clinical trial Jose M. Trigo, Alexandra Soliman, Lena C. Quilty, Benedikt Fischer, JuÈrgen Rehm, Peter Selby, Allan J. Barnes11¤a, Marilyn A. Huestis, Tony P. George, David L. Streiner, Gregory Staios, Bernard Le Foll PLoS ONE, 2018, 13, (1), e0190768. https://doi.org/10.1371/journal.pone.0190768   Abstract Background The current lack of pharmacological treatments for cannabis use disorder (CUD) warrants novel approaches and further investigation of promising pharmacotherapy. We previously showed that nabiximols (27 mg/ml Δ9-tetrahydrocannabinol (THC)/ 25 mg/ml cannabidiol (CBD), Sativex®) can decrease cannabis withdrawal symptoms. Here, we assessed in a pilot study the [...]

Lire la suite

Harm potential of magic mushroom use : A review, Jan van Amsterdam et al., 2011

Harm potential of magic mushroom use : A review Jan van AMSTERDAM, Antoon OPPERTHUIZEN, Wim van den BRINK Regulatory Toxicology and Pharmacology, 2011, 59, 423-429. Doi : 10.1016/j.yrtph.2011.01.006   Abstract In 2007, the Minister of Health of the Netherlands requested the CAM (Coordination point Assessment and Monitoring new drugs) to assess the overall risk of magic mushrooms. The present paper is an updated redraft of the review, written to support the assessment by CAM experts. It summarizes the literature on physical or psychological dependence, acute and chronic toxicity, risk for public health and criminal aspects related to the consumption of magic mushrooms. In the Netherlands, the [...]

Lire la suite

Alessandro Stella, Publications, 2019

Alessandro Stella Directeur de recherche CNRS Equipe(s) : GEI Laboratoire(s) de rattachement : CRH Coordonnées professionnelles EHESS-CRH GEI (Bureau A 04-11) 54, boulevard Raspail 75006 Paris alessandro.stella (a) wanadoo.fr 01 49 54 24 42 http://gei.ehess.fr/index.php?942  Diplômes 1987 : Diplôme de l’EHESS, sous la direction de Mme Christiane Klapisch-Zuber : « Sur les traces laissées par les Ciompi en révolte : les hommes, les lieux, le travail », rapporteur M. Jacques Le Goff. Prix du meilleur diplôme de l’EHESS. 1992 : Doctorat de l’EHESS, sous la direction de Mme Christiane Klapisch-Zuber : « Un tableau florentin du Trecento. Fiscalité, topographie et société dans la deuxième moitié du XIVe siècle ». Mention : « Très honorable ». 2007 : Habilitation à Diriger des Recherches, Université [...]

Lire la suite

Psychedelic therapy in the Czech Republic : A theoretical concept or a realistic goal ?, Zuzana Postranecka et al., 2019

Psychedelic therapy in the Czech Republic : A theoretical concept or a realistic goal ? Zuzana Postranecka, Čestmir Vejmola and Filip Tyls Journal of Psychedelic Studies DOI: 10.1556/2054.2019.003   Abstract Psychedelic research has been associated with the Czech Republic since the early 19th century and, after a long period of involuntary dormancy, it has recently gained new opportunities to follow up on its roots and evolve. This article briefly describes the history of psychedelic research in the Czech Republic, summarizes the role of the UN Drug Conventions, and discusses the Czech and international legislation pertaining to psychedelics. The discussion focuses on the dependence/abuse potential of classical [...]

Lire la suite

A role for cannabidiol in psychiatry? Keep calm and follow the drug development rules, Gabriella Gobbi, 2019

A role for cannabidiol in psychiatry? Keep calm and follow the drug development rules Gabriella Gobbi THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2019, VOL. 20, NO. 2, 98–100 Commentary https://doi.org/10.1080/15622975.2019.1584680   Along with tetrahydrocannabinol (THC), cannabidiol (CBD) is one of the main pharmacological components of Cannabis sativa and indica. Unlike THC, which binds CB1 receptors, CBD does not cause any dependence, and acts mostly via 5-HT1A and TPRV1 receptors (De Gregorio et al. 2018). Khoury et al. (2019) recently published a systematic review on the role of cannabidiol in psychiatry in the World Journal of Biological Psychiatry. After analysing 609 articles, they found six case reports, [...]

Lire la suite