Effects of external stimulation on psychedelic state neurodynamics Pedro A.M. Mediano, Fernando E. Rosas, Christopher Timmermann, Leor Roseman, David J. Nutt, Amanda Feilding, Mendel Kaelen, Morten L. Kringelbach, Adam B. Barretti, Anil K. Seth, Suresh Muthukumaraswamy, Daniel Bor, and Robin L. Carhart-Harris bioRxiv preprint, 2020 doi : 10.1101/2020.11.01.356071 Abstract Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes such as personality changes. These findings are particularly intriguing given that a decrease of brain entropy is a robust indicator of loss of consciousness (e.g. from wakefulness to [...]
Lire la suiteThe Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines Federico Zamberlan, Camila Sanz, Rocío Martínez Vivot, Carla Pallavicini, Fire Erowid, Earth Erowid and Enzo Tagliazucchi Frontiers in Integrative Neuroscience, 2018, 12, 54. doi : 10.3389/fnint.2018.00054 Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of the user (“set”) and the surroundings (“setting”). The observation of crosstolerance and a series [...]
Lire la suitePsilocybine mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects SMIGIELSKI Lukasz, SCHEIDEGGER Milan, KOMETER Michael, VOLLENWEIDER Franz X. NeuroImage, 2019, 196, 207-215 Doi : 10.1016/j.neuroimage.2019.04.009 A B S T R A C T Both psychedelics and meditation exert profound modulatory effects on consciousness, perception and cognition, but their combined, possibly synergistic effects on neurobiology are unknown. Accordingly, we conducted a randomized, double-blind, placebo-controlled study with 38 participants following a single administration of the psychedelic psilocybin (315 μg/kg p.o.) during a 5-day mindfulness retreat. Brain dynamics were quantified directly pre- and post-intervention by functional magnetic resonance imaging during the resting state and [...]
Lire la suiteChapter 1 : You Have a Constitutional Right to Psychedelics. Academic Freedom, Personal Conscience, and Psychotechnologies Thomas B. Roberts From: Ellens, H. J. & T. B. Roberts. 2015. The Psychedelic Policy Quagmire: Health, Law, Freedom, and Society. Santa Barbara, CA. ABC-CLIO. Author’s note: This also applies to the European Charter of Human Rights and to similar national and international statements. Added Mar. 16, 2016. The problem : we do not suppress books and the ideas they contain; we do suppress psychedelic mindstates and the ideas they contain. Censorship is the issue of contention here: intellectual censorship. In this chapter, we’ll spot the single-state fallacy as [...]
Lire la suiteExpanding the Scientific Study of Self-Experience with Psychedelics Manesh Girn and Kalina Christoff Journal of Consciousness Studies, 2018, 25, (11–12), 131–54 Abstract : The nature of the self has long been a topic of discussion in philosophical and religious contexts, and has recently also garnered significant scientific attention. Although evidence exists to suggest the multifaceted nature of self-experience, the amount of research done on each of its putative components has not been uniform. Whereas selfreflective processing has been studied extensively, non-reflective aspects of self-experience have been the subject of comparatively little empirical research. This discrepancy may be linked to the methodological difficulties in experimentally [...]
Lire la suiteImplications for psychedelic-assisted psychotherapy : a functional magnetic resonance imaging study with psilocybin R. L. Carhart-Harris, R. Leech, T. M. Williams, D. Erritzoe, N. Abbasi, T. Bargiotas, P. Hobden, D. J. Sharp, J. Evans, A. Feilding, R. G. Wise and D. J. Nutt British Journal of Psychiatry, 2012, 200, 238-244. Doi : 10.1192/bjp.bp.111.103309 Background Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences. Aims To test the hypothesis that psilocybin facilitates access to personal memories and emotions by comparing subjective and neural responses to positive [...]
Lire la suiteFunctional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Robin L. Carhart-Harris, Robert Leech, David Erritzoe, Tim M. Williams, James M. Stone, John Evans, David J. Sharp, Amanda Feilding, Richard G. Wise, and David J. Nutt Schizophrenia Bulletin, 2012, Volume 39, Issue 6, November 2013, Pages 1343–1351 doi : 10.1093/schbul/sbs117 Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamo-cortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in 2 task-free resting-state scans. Primary analyses focused on [...]
Lire la suiteFreudian, Jungian, Grofian — Steps Toward the Psychedelic Humanities Thomas B. Roberts, Ph.D. The Journal of Transpersonal Psychology, 2017, Vol. 49, No. 2, 19 p. Copyright 2017, Transpersonal Institute ABSTRACT: Stanislav Grof’s map of the mind offers transpersonalists — and further, humanists and all professions working with the human phenomenon — a new kind of intellectual effort. Just as Freudian and Jungian psychologies enriched 20th Century intellectual life, Grofian is enriching the 21st. Grof’s psychedelic-derived theory promotes cultural interpretation, psychocriticism, curricular enrichment, and new methods of humanistic research. The theory’s four-level map of the human mind has received moderate attention primarily by confirming other [...]
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