Cannabinoid Addiction: Behavioral Models and Neural Correlates Rafael Maldonado and Fernando Rodriguez de Fonseca The Journal of Neuroscience, 2002, 22, (9), 3326–3331. Abstract The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid abuse have been developed only recently. We review these models and the role of the CB1 cannabinoid receptor, the main target of natural cannabinoids, and its interaction with opioid and dopamine transmission in reward circuits. Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., [...]
Lire la suiteThe effects of Δ9-tetrahydrocannabinol on the dopamine system Michael A P Bloomfield, Abhishekh H Ashok, Nora D Volkow, and Oliver D Howes Nature, 2016, 539, 7629, 369–377. doi : 10.1038/nature20153. Preface Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, is a pressing concern to global mental health. Patterns of use are changing drastically due to legalisation, availability of synthetic analogues (‘spice’), cannavaping and aggrandizements in the purported therapeutic effects of cannabis. Many of THC’s reinforcing effects are mediated by the dopamine system. Due to complex cannabinoid-dopamine interactions there is conflicting evidence from human and animal research fields. Acute THC causes increased dopamine release and neuron [...]
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