Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth Calvin Ly, Alexandra C. Greb, Maxemiliano V. Vargas, Whitney C. Duim, Ana Cristina G. Grodzki, Pamela J. Lein, and David E. Olson ACS Pharmacology and Translational Science, 2020. doi : 10.1021/acsptsci.0c00065 ABSTRACT Cortical neuron atrophy is a hallmark of depression and includes neurite retraction, dendritic spine loss, and decreased synaptic density. Psychoplastogens, small molecules capable of rapidly promoting cortical neuron growth, have been hypothesized to produce long-lasting positive effects on behavior by rectifying these deleterious structural and functional changes. Here we demonstrate that ketamine and LSD, psychoplastogens from two structurally distinct chemical classes, promote [...]
Lire la suiteChanges in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca Nicole Leite Galvão-Coelho, Ana Cecília de Menezes Galvão, Raíssa Nóbrega de Almeida, Fernanda Palhano-Fontes, Isaac Campos Braga, Bruno Lobão Soares, João Paulo Maia-de-Oliveira, Daniel Perkins, Jerome Sarris and Draulio Barros de Araujo Journal of Psychopharmacology, 2020, 1-9. DOI : 10.1177/0269881120936486 Abstract Background : Ayahuasca is a traditional Amazon brew and its potential antidepressant properties have recently been explored in scientific settings. We conducted a double-blind placebo-controlled trial of ayahuasca with treatment-resistant depression patients (n = 28) and healthy controls (n = 45). Aims : We are evaluating the blood inflammatory biomarkers: C-reactive protein and [...]
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