Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential ? Rita Kocárová, Jirí Horácek and Robin Carhart-Harris Frontiers in Psychiatry, July 2021, Volume 12, Article 661233, 1-18. doi : 10.3389/fpsyt.2021.661233 Addressing global mental health is a major 21st-century challenge. Current treatments have recognized limitations; in this context, new ones that are prophylactic and effective across diagnostic boundaries would represent a major advance. The view that there exists a core of transdiagnostic overlap between psychiatric disorders has re-emerged in recent years, and evidence that psychedelic therapy holds promise for a range of psychiatric disorders supports the position that it may be transdiagnostically effective. Here, [...]
Lire la suitePsychedelic perceptions: mental health service user attitudes to psilocybin therapy Kate Corrigan · Maeve Haran · Conor McCandliss · Roisin McManus · Shannon Cleary · Rebecca Trant · Yazeed Kelly · Kathryn Ledden · Gavin Rush · Veronica O’Keane · John R. Kelly Irish Journal of Medical Science (1971 -), 2021, 1-13. Doi : 10.1007/s11845-021-02668-2 Abstract Introduction : Despite the rapid advance of psychedelic science and possible translation of psychedelic therapy into the psychiatric clinic, very little is known about mental health service user attitudes. Objectives : To explore mental health service user attitudes to psychedelics and psilocybin therapy. Methods : A questionnaire capturing demographics, diagnoses, previous [...]
Lire la suiteRediscovering Psilocybin as an Antidepressive Treatment Strategy Rene Zeiss, Maximilian Gahr and Heiko Graf Pharmaceuticals, 2021, 14, 985, 1-14. doi : 10.3390/ph14100985 Abstract : There has recently been a renewal of interest in psychedelic research on the use of psilocybin in psychiatric treatment and, in particular, for the treatment of major depressive disorder (MDD). Several state-of-the-art studies have provided new insight into the mechanisms of action of psilocybin and its therapeutic potential. Nevertheless, many questions remain unanswered. With this review, we provide an overview of the current state of research on the potential mechanisms of psilocybin, its antidepressant potential, and the associated risks [...]
Lire la suiteNew psychoactive substances: a review and updates Abu Shafi, Alex J. Berry, Harry Sumnall, David M. Wood and Derek K. Tracy Therapeutic Advances in Psychopharmacology, 2020, Vol. 10, 1–21. Doi : 10.1177/2045125320967197 Abstract : New psychoactive substances (NPS) are a heterogeneous group of substances. They are associated with a number of health and social harms on an individual and societal level. NPS toxicity and dependence syndromes are recognised in primary care, emergency departments, psychiatric inpatient and community care settings. One pragmatic classification system is to divide NPS into one of four groups: synthetic stimulants, synthetic cannabinoids, synthetic hallucinogens and synthetic depressants (which include synthetic opioids [...]
Lire la suiteMolecular Mechanisms of Action of Novel Psychoactive Substances (NPS). A New Threat for Young Drug Users with Forensic-Toxicological Implications Arianna Giorgetti, Jennifer P. Pascali, Paolo Fais, Guido Pelletti, Andrea Gabbin, Giorgia Franchetti, Giovanni Cecchetto and Guido Viel Life, 2021, 11, 440, 1-17. doi : 10.3390/life11050440 Abstract : Novel psychoactive substances (NPS) represent a severe health risk for drug users. Even though the phenomenon has been growing since the early 2000s, the mechanisms of action of NPS at the receptors and beyond them are still scarcely understood. The aim of the present study was to provide a systematic review of the updated knowledge regarding the molecular [...]
Lire la suite”State of the art on psychedelic research" Iker Puente, PhD Integral European Conference (IEC) Siófok, Hungary, 27 May 2018 Psychedelic psychotherapy and research: history 1st Phase: 1947-1970. First studies and beginning of research. 2nd Phase: 1971-1989. Prohibition of studies and other uses. 3nd Phase: 1990-2005. Beginning of new studies and research. 4rd Phase: 2006-2016. Positive outcomes, change of social perception, blossoming of research, publications and positive media coverage. Today: many studies in some of the most prestigious universities of the world: Johns Hopkins, Harvard, NYU, UCLA, Imperial College London… using MDMA, psilocybin, ketamine, LSD… (...)
Lire la suiteOn the Archetypal Nature of Bad Trips and Freakouts A Review of : "Confrontation With the Unconscious: Jungian Depth Psychology and Psychedelic Experience" by Scott J. Hill Danny Wedding, Peter H Addy PsycCRITIQUES, June 16, 2014, Vol. 59, No. 24, Article 4 © 2014 American Psychological Association In 1967 Scott J. Hill had a terrifying and traumatic experience after taking LSD, experiencing “the depths of madness and hell” (p. xiii). He became suicidal and dissociated, and he wondered whether he had gone insane. Over the next four decades, he struggled with the terror he felt during that experience; he could not come to terms with [...]
Lire la suiteLearning to Let Go : A Cognitive-Behavioral Model of How Psychedelic Therapy Promotes Acceptance Max Wolff, Ricarda Evens, Lea J. Mertens, Michael Koslowski, Felix Betzler, Gerhard Gründer and Henrik Jungaberle Frontiers in Psychiatry, February 2020 | Volume 11 | Article 5, 1-13. doi : 10.3389/fpsyt.2020.00005 The efficacy of psychedelic-assisted therapies for mental disorders has been attributed to the lasting change from experiential avoidance to acceptance that these treatments appear to facilitate. This article presents a conceptual model that specifies potential psychological mechanisms underlying such change, and that shows substantial parallels between psychedelic therapy and cognitive behavioral therapy: We propose that in the carefully controlled [...]
Lire la suitePsychedelic Medicines for Mood Disorders Current Evidence and Clinical Considerations Jerome Sarris; Diego Pinzon Rubiano; Kimberley Day; Nicole L. Galvão-Coelho; Daniel Perkins Current Opinion in Psychiatry, 2022, 35, (1), 22-29. doi : 10.1097/YCO.0000000000000759 https://www.medscape.com/viewarticle/964245 Abstract and Introduction Abstract Purpose of Review: Despite advances in treatment modalities for mood disorders over recent decades, further therapeutic options are still required. Increased research is occurring, with the pursuit of psychedelic-based pharmacotherapies for a range of mood disorders and other conditions. Recent Findings: Serotonergic psychedelics have been found to modulate brain networks underlying various psychiatric disorders, as well promoting neurogenesis and neuroplasticity. Randomized placebo-controlled trials have found psilocybin with psychological support effective at [...]
Lire la suiteNovel Treatment Approaches for Substance Use Disorders : Therapeutic Use of Psychedelics and the Role of Psychotherapy Michael Koslowski, Matthew W. Johnson, Gerhard Gründer, Felix Betzler Current Addiction Reports, 2021, 1-11. doi : 10.1007/s40429-021-00401-8 Abstract Purpose of Review : The use of psychedelics in a therapeutical setting has been reported for the treatment of various diagnoses in recent years. However, as psychedelic substances are still commonly known for their (illicit) recreational use, it may seem counterintuitive to use psychedelic therapy to treat substance use disorders. This review aims to discuss how psychedelics can promote and intensify psychotherapeutic key processes, in different approaches like psychodynamic and [...]
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