Cannabinoids in Parkinson's Disease Mario Stampanoni Bassi, Andrea Sancesario, Roberta Morace, Diego Centonze, and Ennio Iezzi Cannabis and Cannabinoid Research, 2017, Volume 2.1 DOI: 10.1089/can.2017.0002 Abstract The endocannabinoid system plays a regulatory role in a number of physiological processes and has been found altered in different pathological conditions, including movement disorders. The interactions between cannabinoids and dopamine in the basal ganglia are remarkably complex and involve both the modulation of other neurotransmitters (c-aminobutyric acid, glutamate, opioids, peptides) and the activation of different receptors subtypes (cannabinoid receptor type 1 and 2). In the last years, experimental studies contributed to enrich this scenario reporting interactions between cannabinoids [...]
Lire la suitePredicting Responses to Psychedelics : A Prospective Study Eline C. H. M. Haijen, Mendel Kaelen, Leor Roseman, Christopher Timmermann, Hannes Kettner, Suzanne Russ, David Nutt, Richard E. Daws, Adam D. G. Hampshire, Romy Lorenz and Robin L. Carhart-Harris Frontiers in Pharmacology, 2018 doi: 10.3389/fphar.2018.00897 Abstract Responses to psychedelics are notoriously difficult to predict, yet significant work is currently underway to assess their therapeutic potential and the level of interest in psychedelics among the general public appears to be increasing. We aimed to collect prospective data in order to improve our ability to predict acute- and longer-term responses to psychedelics. Individuals who planned to take a [...]
Lire la suiteHow Adolescents with Autism Spectrum Disorder (ASD) Spontaneously Attend to Real-World Scenes : Use of a Change Blindness Paradigm Michal Hochhauser, Adi Aran, Ouriel Grynszpan Journal of Autism and Developmental Disorders, 2018, 48, 502–510 DOI 10.1007/s10803-017-3343-6 https://www.researchgate.net/publication/320647151_How_Adolescents_with_Autism_Spectrum_Disorder_ASD_Spontaneously_Attend_to_Real-World_Scenes_Use_of_a_Change_Blindness_Paradigm [accessed Jul 16 2019]. Abstract Visual attention of adolescents with autism spectrum disorder (ASD) was assessed using a change blind-ness paradigm. Twenty-five adolescents with ASD aged 12–18 years and 25 matched typically developing (TD) adolescents viewed 36 pairs of digitized real-world images. Each pair of images was displayed in a ‘flicker paradigm’ whereby a particular item alternately appeared and disappeared. This item was either a central or a marginal [...]
Lire la suiteQualitative and Quantitative Features of Music Reported to Support Peak Mystical Experiences during Psychedelic Therapy Sessions Frederick S. Barrett, Hollis Robbins, David Smooke, Jenine L. Brown and Roland R. Griffiths Frontiers in Psychology, 2017 ORIGINAL RESEARCH published: 25 July 2017 doi: 10.3389/fpsyg.2017.01238 Abstract Psilocybin is a classic (serotonergic) hallucinogen (“psychedelic” drug) that may occasion mystical experiences (characterized by a profound feeling of oneness or unity) during acute effects. Such experiences may have therapeutic value. Research and clinical applications of psychedelics usually include music listening during acute drug effects, based on the expectation that music will provide psychological support during the acute effects of psychedelic drugs, and [...]
Lire la suiteBeyond LSD : A Broader Psychedelic Zeitgeist during the Early to Mid-20th Century Jacob S. Aday, M.S. , Emily K. Bloesch, Ph.D. , and Christopher C. Davoli, Ph.D. Journal of Psychoactive Drugs, 2019 https://doi.org/10.1080/02791072.2019.1581961 ABSTRACT During the 1950s and 1960s, there was a tremendous surge in research into the effects of psychedelic drugs. When discussing this period of research, the discovery of the psychoactive properties of LSD in 1943 is often presented as the main, and sometimes only, driving force of the boom in research. This “Great Person,” or “Great Chemical,” historiographical lens fails to acknowledge other factors that were fundamental in setting the stage [...]
Lire la suiteEmotional breakthrough and psychedelics : Validation of the Emotional Breakthrough Inventory Leor Roseman, Eline Haijen, Kelvin Idialu-Ikato, Mendel Kaelen, Rosalind Watts and Robin Carhart-Harris Journal of Psychopharmacology, 2019, 1–12 DOI: 10.1177/0269881119855974 Abstract Background : Psychedelic therapy is gaining recognition and the nature of the psychedelic experience itself has been found to mediate subsequent long-term psychological changes. Much emphasis has been placed on the occurrence of mystical-type experiences in determining long-term responses to psychedelics yet here we demonstrate the importance of another component, namely: emotional breakthrough. Methods : Three hundred and seventy-nine participants completed online surveys before and after a planned psychedelic experience. Items pertaining to emotional [...]
Lire la suiteThe Meaning-Enhancing Properties of Psychedelics and Their Mediator Role in Psychedelic Therapy, Spirituality, and Creativity Ido Hartogsohn Frontiers in Neurosciences, 06 March 2018 | https://doi.org/10.3389/fnins.2018.00129 Past research has demonstrated to the ability of psychedelics to enhance suggestibility, and pointed to their ability to amplify perception of meaning. This paper examines the existing evidence for the meaning-enhancing properties of psychedelics, and argues that the tendency of these agents to enhance the perception of significance offers valuable clues to explaining their reported ability to stimulate a variety of therapeutic processes, enhance creativity, and instigate mystical-type experiences. Building upon previous research, which suggested the potential role of [...]
Lire la suitePeter Webster added a comment to the article : REBUS and the Anarchic Brain : Toward a Unified Model of the Brain Action of Psychedelicss R. L. Carhart-Harris and K. J. Friston, Pharmacological Reviews, 2019, 71, 316–344 https://doi.org/10.1124/pr.118.017160 https://www.grecc.org/publications/ressources-documentaires/pharmacologie/rebus-and-the-anarchic-brain-toward-a-unified-model-of-the-brain-action-of-psychedelics-r-l-carhart-harris-and-k-j-friston-2019/ Prediction : ultimately you will find that the Salience Network has a far greater importance for understanding psychedelic experience than the DMN. See: Menon V. (2015) Salience Network. In: Arthur W. Toga, editor. Brain Mapping: An Encyclopedic Reference, vol. 2, p. 597. Academic Press: Elsevier. In Doors of Perception, Aldous Huxley writes, [I was seeing] a bunch of flowers shining with their own inner light and all but quivering under the [...]
Lire la suiteIbogaine and Subjective Experience : Transformative States and Psychopharmacotherapy in the Treatment of Opioid Use Disorder Thomas K. Brown, PhDa, Geoff E. Noller, PhDb, and Julie O. Denenberg, MAc Journal of Psychoactive Drugs, 2019 https://doi.org/10.1080/02791072.2019.1598603 ABSTRACT This article examines the therapeutic potential of ibogaine, a powerful oneiric alkaloid derived from Tabernanthe iboga, through exploring the subjective experiences of 44 participants from two observational treatment studies for opioid use disorder. Following treatment with ibogaine HCl, the participants (Mexico, n = 30; New Zealand, n = 14) completed the States of Consciousness Questionnaire (SCQ) to quantify the magnitude of their psychotropic experience. Participants were asked to provide [...]
Lire la suiteLe cannabidiol en traitement «anti-addictif» chez les patients alcooliques : l’étude CARAMEL PHRC-N 2018 n°0198 Investigateur principal B. Rolland François Bailly, service d’hépatologie et d’addictologie, Hôpital de la Croix Rousse, Lyon. Le cannabidiol en traitement « anti-addictif » chez les patients alcooliques : l’étude CARAMEL François Bailly Hôpital de la Croix-Rousse, Lyon Le protocole CARAMEL, qui devrait démarrer début 2020, est destiné à étudier l’intérêt du cannabidiol dans la dépendance alcoolique. Le projet d’étude est centré sur les effets du CBD sur le système nerveux central et les neuroprotecteurs et antioxydants, qui ont un impact sur la toxicité de l’alcool au niveau du cerveau et du foie, [...]
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