BIBLIOGRAPHIE : Beta-Carbolines Harmine, Harmane, Harmaline, Nor-harmane, Harmol, Harmalol, Tetrahydroharmine β-Carbolines et Thérapeutique en Psychiatrie, p. 6. (cf également Bibliographie : Peganum harmala, p. 7 ci-dessous, et Bibliographie : Amanita muscaria, et Bibliographie : Ayahuasca) Dr Christian SUEUR, GRECC, décembre 2019.
Lire la suiteCannabidiol Protects Dopaminergic Neuronal Cells from Cadmium Jacopo Junio Valerio Branca, Gabriele Morucci, Matteo Becatti, Donatello Carrino, Carla Ghelardini, Massimo Gulisano, Lorenzo Di Cesare Mannelli Alessandra Pacini International Journal of Environmental Research and Public Health, 2019, 16, 4420. doi : 10.3390/ijerph16224420 Abstract The protective effect of cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, against neuronal toxicity induced by cadmium chloride (CdCl2 10 M) was investigated in a retinoic acid (RA)-dierentiated SH-SY5Y neuroblastoma cell line. CBD (1 M) was applied 24 h before and removed during cadmium (Cd) treatment. In dierentiated neuronal cells, CBD significantly reduced the Cd-dependent decrease of cell viability, and the rapid [...]
Lire la suiteIACM-Bulletin du 06 Décembre 2019 Science/Homme: Le cannabis riche en CBD pourrait être utile dans l'autisme Science/Homme: Le cannabis peut être utile dans le traitement de l'endométriose Science/Homme: Un extrait de chanvre riche en CBD peut réduire l'utilisation d'opiacés chez les patients souffrant de douleur chronique États-Unis: Un Comité de la Chambre des Représentants adopte un projet de loi historique visant à décriminaliser le cannabis Royaume-Uni: 20 000 patients bénéficieront d'un essai de cannabis médical En bref Un coup d'œil sur le passé Science/Homme: Le cannabis riche en CBD pourrait être [...]
Lire la suiteEndocannabinoid System Aleksandra Tarasiuka, Maciej Salagaa, and Jakub Fichna Encyclopedia of Gastroenterology, 2nd Edition, 2019 © 2019 Elsevier Inc. All rights reserved. https://doi.org/10.1016/B978-0-12-801238-3.65635-0 1 Introduction 1 Cannabinoids and Their Role in the Physiological and Pathophysiological Processes in the GI Tract 3 Physiological Conditions 3 Gut motility 3 Gastric secretion and emptying 3 Pathophysiological Conditions 4 IBS 4 IBD 5 Colon cancer 5 Peptic ulcer disease 5 Endocannabinoid System and Its Interplay With Other Systems 5 Cholecystokinin 5 Endovanilloids 6 Opioids 6 Endocannabinoid System and Gut Microbiota 6 Conclusion 7 Acknowledgments 7 References Introduction Endocannabinoid system (ECS) is one of the crucial physiological systems that may be targeted to improve human health. Endocannabinoids and their receptors are localized in various organs (heart, lungs, urinary bladder, [...]
Lire la suitePsychedelic Experiential Pharmacology : Pioneering Clinical Explorations with Salvador Roquet (How I Came to All of This : Ketamine, Admixtures and Adjuvants, Don Juan and Carlos Castaneda Too) An Interview with Richard Yensen Philip E. Wolfson International Journal of Transpersonal Studies, 2014, 33, (2), 160-174. Richard Yensen was a research fellow at the Maryland Psychiatric Research Center from 1972 to 1976. He studied psychedelic psychotherapy with Stanislav Grof, M.D. and other senior staff. During this time he treated patients with substance abuse disorders, cancer, neurosis, and other health professionals seeking a training experience. Dr. Yensen did his Ph.D. dissertation on the use of MDA in [...]
Lire la suiteNo Link Between Marijuana Use and Cancer, Except TGCT Nick Mulcahy Medscape Psychiatry, November 27, 2019 https://www.medscape.com/viewarticle/921889?nlid=132907_2052&src=WNL_mdplsnews_191206_mscpedit_psyc&uac=292598PZ&spon=12&impID=2194053&faf=1 More than 10 years of marijuana use is associated with the development of testicular germ cell tumor (TGCT), but the quality of the evidence is "low strength" and there is insufficient evidence to support an association between ever having used marijuana and other types of cancer. These are the conclusions from a new systematic review and meta-analysis published online today in JAMA Open Network. Lead author Mehrnaz Ghasemiesfe, MD, Northern California Institute of Research and Education, San Francisco, and colleagues explain that they wondered if marijuana smoke might cause [...]
Lire la suiteModulation of Social Cognition via Hallucinogens and “Entactogens” Katrin H. Preller and Franz X. Vollenweider Frontiers in Psychiatry, décembre 2019 doi: 10.3389/fpsyt.2019.00881 Social cognition is a fundamental ability in human everyday lives. Deficits in social functioning also represent a core aspect of many psychiatric disorders. Yet, despite its significance, deficits in social cognition skills are insufficiently targeted by current treatments. Hallucinogens and entactogens have been shown to have the potential to modulate social processing. This article reviews the literature on the influence of hallucinogens and entactogens on social processing in controlled experimental studies in humans and elucidates the underlying neurobiological and neuropharmacological mechanisms. Furthermore, [...]
Lire la suiteCannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus Through Bi-Directional Control of ERK1-2 Phosphorylation Roger Hudson, Justine Renard, Christopher Norris, Walter J. Rushlow and Steven R. Laviolette The Journal of Neuroscience, 2019 https://doi.org/10.1523/JNEUROSCI.0708-19.2019 Abstract Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral hippocampus (vHipp) relays emotional salience via control of dopamine (DA) neuronal activity states, which are dysregulated in psychosis and schizophrenia. Using in-vivo electrophysiology in male Sprague Dawley rats, we demonstrate that intra-vHipp THC strongly increases ventral tegmental area (VTA) DA neuronal frequency and bursting rates, decreases GABA frequency, and [...]
Lire la suiteCBD Oil: An Introduction Zoe Sigman 2019 https://www.projectcbd.org/cbd-101/what-is-cbd-oil Medical patients swear by it. Researchers are intrigued by it. Government regulators are flustered by it. And investors are head over heels for it. CBD oil is the It-Medicine of the moment. A few years ago, hardly anyone knew about CBD oil. Today there’s a huge demand for it. Millions of people are taking CBD oil as a health supplement. But what exactly is it? Where does it come from? How is it made? And what should you know before you buy it? Where Does CBD Oil Come From ? Cannabidiol (CBD) is one of more than 100 unique “cannabinoid” [...]
Lire la suiteMolecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites Chun Yang, Jianjun Yang, Ailin Luo and Kenji Hashimoto Translational Psychiatry, 2019, 9, 280 doi : 10.1038/s41398-019-0624-1 Abstract Although the robust antidepressant effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine in patients with treatment-resistant depression are beyond doubt, the precise molecular and cellular mechanisms underlying its antidepressant effects remain unknown. NMDAR inhibition and the subsequent α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid receptor (AMPAR) activation are suggested to play a role in the antidepressant effects of ketamine. Although (R)-ketamine is a less potent NMDAR antagonist than (S)-ketamine, (R)-ketamine has shown more marked and longer-lasting antidepressant-like [...]
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