Auteur : GRECC

Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids, Ramia Z. Al Bakain et al., 2019

Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids Ramia Z. Al Bakain, Yahya S. Al-Degs, James V. Cizdziel and Mahmoud A. Elsohly Journal of Liquid Chromatography & Related Technologies, 2019 Doi : 10.1080/10826076.2019.1701015   ABSTRACT Different USA-origin cannabis samples were analyzed by GC-FID to quantify all possible cannabinoids and terpenoids prior to their clustering. Chromatographic analysis confirmed the presence of seven cannabinoids and sixteen terpenoids with variable levels. Among tested cannabinoids, D9-Tetrahydro-cannabinol D9-THC and cannabinol CBN were available in excess amounts (1.2–8.0 wt%) and (0.22–1.1 wt%), respectively. Fenchol was the most abundant terpenoid with a range of (0.03–1.0 wt%). [...]

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Cannabinoid receptor expression in nonsmall cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelialmesenchymal transition in vitro, Lara Milian et al., 2020

Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial mesenchymal transition in vitro Lara Milian, Manuel Mata, Javier Alcacer, Marıa Oliver, Marıa Sancho-Tello, Jose Javier Martın de Llano, Carlos Camps, Jose Galbis, Julian Carretero, Carmen Carda PLoS ONE, 2020, 15, (2): e0228909. Doi : 10.1371/journal.pone.0228909   Abstract Background/Objective : Patients with non-small cell lung cancer (NSCLC) develop resistance to antitumor agents by mechanisms that involve the epithelial-to-mesenchymal transition (EMT). This necessitates the development of new complementary drugs, e.g., cannabinoid receptors (CB1 and CB2) agonists including tetrahydro-cannabinol (THC) and cannabidiol (CBD). The combined use of THC and CBD [...]

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Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients, Jeffrey Y. Hergenrather et al., 2020

Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients Jeffrey Y. Hergenrather, Joshua Aviram, Yelena Vysotski, Salvatore Campisi-Pinto, Gil M. Lewitus and David Meiri. Rambam Maimonides Medical Journal, 2020, 11, (1), e0001 Doi : 10.5041/RMMJ.10384   Methods : Participants were adult patients licensed for medical cannabis (MC) treatment who also reported a diagnosis of ADHD by a physician. Data on demographics, ADHD, sleep, and anxiety were collected using self-report questionnaires. Data collected on MC treatment included administration route, cultivator, cultivar name, and monthly dose. Comparison statistics were used to evaluate differences in reported parameters between low (20–30 g, n=18) and [...]

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Is There a Role for Cannabis in Mental Health Disorders ? Pauline Anderson & Charles P. Vega, 2019

Is There a Role for Cannabis in Mental Health Disorders ? Pauline Anderson & Charles P. Vega, Medscape, CME / ABIM MOC / CE Released : 12/13/2019 https://www.medscape.org/viewarticle/922367   Clinical Context The most common indication for the use of medicinal cannabis is pain, although the results of studies of cannabis products for chronic pain are mixed. Häuser and colleagues performed a review of systematic reviews of cannabis for chronic pain conditions, and their results were published in the October 15, 2017 issue of European Journal of Pain.[1] Reviewers evaluated 10 systematic reviews of cannabis for pain. Methodological quality was high in 4 of the reviews. There was [...]

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Cannabidiol treatment in an adolescent with multiple substance abuse, social anxiety and depression, Clarissa Laczkovics et al., 2020

Cannabidiol treatment in an adolescent with multiple substance abuse, social anxiety and depression. Case Report Clarissa Laczkovics · Oswald D. Kothgassner · Anna Felnhofer · Claudia M. Klier Neuropsychiatrie, 2020, 4 p. Doi : 10.1007/s40211-020-00334-0 Summary In this report, we present a case of a 16,9- year-old patient with multiple substance use disorder (cannabis, MDMA, cocaine, ecstacy), severe depression, social phobia and narcissistic personality disorder. We administered Cannabidiol (CBD) capsules in different dosages (starting dosage 100 mg up to 600 mg over 8 weeks) after unsuccessful treatment with antidepressants. CBD was a safe and well tolerated medication for this patient. Upon treatment with CBD and [...]

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IACM-Bulletin du 18 Février 2020

IACM-Bulletin du 18 Février 2020 IACM: Conférences en novembre 2020 à Mexico et en octobre 2021 à Bâle Science/Homme: Un nombre croissant de patients atteints de maladies rhumatismales aux États-Unis consomment du cannabis Science/Homme: L’arrêt de l'utilisation du CBD ne provoque pas de symptômes de sevrage Science/Homme: Après l'adoption des lois sur le cannabis médical aux États-Unis, l'indemnisation des accidents du travail a été réduite Science/Homme: La consommation de cannabis est associée à une réduction des symptômes du TDAH En bref Un coup d'œil sur le passé IACM: Conférences en novembre [...]

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Constructing drug effects : A history of set and setting, Ido Hartogsohn, 2017

Constructing drug effects : A history of set and setting Ido Hartogsohn Drug Science, Policy and Law, 2017, 3, (0) 1–17 Doi : 10.1177/2050324516683325   Abstract Set and setting is a term which refers to the psychological, social, and cultural parameters which shape the response to psychedelic drugs. The concept is considered fundamental to psychedelic research and has also been used to describe nonpharmacological factors which shape the effects of other agents such as alcohol, heroin, amphetamines, or cocaine. This paper reviews the history and evolution of the concept of set and setting from the 19th-century Parisian Club des Hashischins, through to 1950s psychotomimetic research on [...]

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Harmful Effects of Smoking Cannabis : A Cerebrovascular and Neurological Perspective, Sabrina Rahman Archie et al., 2019

Harmful Effects of Smoking Cannabis : A Cerebrovascular and Neurological Perspective Sabrina Rahman Archie and Luca Cucullo Frontiers in Pharmacology, 2019, 10, Article 1481. doi : 10.3389/fphar.2019.01481   Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the widespread popularity of it among young population. Various studies have reported about the relationship between cannabis use and different detrimental effects like cardiovascular, cerebrovascular, and neurological complications among different age groups. Specifically, the young population is [...]

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Cannabis use in pediatric cancer patients : what are they reading ? A review of the online literature, M. Yeung et al., 2020

Cannabis use in pediatric cancer patients : what are they reading ? A review of the online literature. YEUNG M., WROOT H., CHARNOCK C., FORBES C., LAFAY-COUSIN L., SCHULTE F. Support Care Cancer, 2020. doi: 10.1007/s00520-020-05306-2 Abstract BACKGROUND: Recent changes to the legal status of marijuana in Canada warrant a review of the information that patients and families are accessing online regarding the role of cannabis in cancer. The aims of the current research were to identify the quality of literature available online as well as the themes, and opinion (i.e., pro-, neutral, or anti-cannabis) of online articles. METHODS: Searches were conducted using three primary search engines: Google, [...]

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Ketamine Promising in Cocaine Addiction, Batya Swift Yasgur, 2019

Ketamine Promising in Cocaine Addiction Batya Swift Yasgur, MA, LSW Medscape.com, July 05, 2019 https://www.medscape.com/viewarticle/915260_print   A single ketamine infusion combined with mindfulness-based relapse prevention therapy (MBRP) improves abstinence and cuts cravings in cocaine-dependent adults, new research suggests. Results of a randomized control trial show that rates of abstinence were significiantly higher in patients who received ketamine plus MBRP compared to control patients. Moreover, those in the group that received ketamine were significantly less likely to experience relapse compared to control persons, and cravings were also significantly lower in the ketamine group throughout the trial. "In individuals receiving MBRP, a single ketamine infusion led to significantly greater odds [...]

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