EMA Panel Backs Esketamine Nasal Spray for Resistant Depression Megan Brooks Medscape Medical News, October 18, 2019 The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended approval of esketamine nasal spray (Spravato, Janssen-Cilag) in combination with a selective serotonin reuptake inhibitor (SSRI) or serotonin and norepinephrine reuptake inhibitor (SNRI) for adults with treatment-resistant major depressive disorder (TRD). Patients are considered to have TRD if they have not responded to at least two different treatments with antidepressants in the current moderate to severe depressive episode. Spravato will be available as a 28 mg nasal spray solution. The safety and [...]
Lire la suiteThe therapeutic potential of harmine and ayahuasca in depression : Evidence from exploratory animal and human studies Flávia de Lima Osório, Ligia Ribeiro Horta de Macedo, João Paulo Machado de Sousa, Joel Porfírio Pinto, João Quevedo, José Alexandre de Souza Crippa and Jaime Eduardo C. Hallak The Ethnopharmacology of Ayahuasca, chapitre 5, 2011, 75-85 Editor : Rafael Guimarães dos Santos ISBN: 978-81-7895-526-1 Abstract The high prevalence and the socio-functional impairment associated with depressive disorders, added to the limitations of currently available treatments, justify the search for novel pharmacological strategies for the management of depression. This chapter presents the major results of animal and human studies conducted [...]
Lire la suiteAyahuasca for Addiction ? That's a Trip Ayahuasca has long been used to heal the spirit, so what about addiction? Adi Jaffe, Psychology Today Posted Dec 10, 2018 https://www.psychologytoday.com/us/blog/all-about-addiction/201812/ayahuasca-addiction-thats-trip Doctors have been prescribing drugs to treat substance addictions for decades. Most commonly known is the use of buprenorphine and naloxone (Suboxone) in opioid addiction which provides some opioid activation, helping with withdrawal and cravings, without the same “high” and many of the associated psychosocial effects of illicit drug use. But Suboxone isn’t the only one – methadone, modafinil, naltrexone, ketamine, and many more examples exist in which the use of a chemical has been prescribed to help [...]
Lire la suiteCannabis thérapeutique : si tout va bien il ne sera pas disponible avant un certain temps Journalisme et Santé Publique Le blog de Jean-Yves Nau, journaliste et docteur en médecine 17 Octobre 2019 https://jeanyvesnau.com/2019/10/17/cannabis-therapeutique-si-tout-va-bien-il-ne-sera-pas-disponible-avant-un-certain-temps/ Bonjour Le temps de l’administration du médicament n’est pas celui du patient souffrant. Il y a un an on découvrait un mouvement de l’Agence nationale de sécurité médicament (ANSM) : « Évaluation de la pertinence et de la faisabilité de la mise à disposition du cannabis thérapeutique en France ». On apprenait alors qu’un Comité Scientifique Spécialisé Temporaire créé pour un an, aurait pour mission « d’évaluer la pertinence de développer en France l’utilisation thérapeutique du cannabis pour [...]
Lire la suiteAyahuasca in Adolescence : A Neuropsychological Assessment Evelyn Doering-Silveira, Enrique Lopez, Charles S. Grob, Marlene Dobkin de Rios, Luisa K. Alonso, Cristiane Tacla,Itiro Shirakawa, Paulo H. Bertolucci, & Dartiu X. Da Silveira Journal of Psychoactive Drugs, 2005, 37, (2), 123-128. Abstract The purpose of the study was to evaluate neuropsychologically adolescents who use ayahuasca in a religious context. A battery of neuropsychological tests was administered to adolescents who use ayahuasca. These subjects were compared to a matched control group of adolescents who did not use ayahuasca. The controls were matched with regards to sex, age, and education. The neuropsychological battery included tests of speeded [...]
Lire la suiteAyahuasca in Adolescence : A Preliminary Psychiatric Assessment Dartiu Xavier Da Silveira; Charles S. Grob; Marlene Dobkin de Rios; Enrique Lopez; Luisa K. Alonso; Cristiane Tacla & Evelyn Doering-Silveira Journal of Psychoactive Drugs, 2005, 37, (2), 129-133. www.neip.info Abstract Ayahuasca is believed to be harmless for those (including adolescents) drinking it within a religious setting. Nevertheless controlled studies on the mental/ psychiatric status of ritual hallucinogenic ayahuasca concoction consumers are still lacking. In this study, 40 adolescents from a Brazilian ayahuasca sect were compared with 40 controls matched on sex, age, and educational background for psychiatric symptomatology. Screening scales for depression, anxiety, alcohol consumption patterns (abuse), [...]
Lire la suiteEffects of a Psychedelic, Tropical Tea, Ayahuasca, on the Electroencephalographic (EEG) Activity of the Human Brain during a Shamanistic Ritual Erik Hoffmann, Jan M. Keppel Hesselink, Yatra-W.M. da Silveira Barbosa MAPS Bulletin, Multidisciplinary Association for Psychedelic Studies, USA, Spring 2001, pp 25-30 Abstract Eight channels of EEG from 12 volunteers participating in a workshop in Brazil were recorded under field conditions before and after a shamanistic ritual in which the psychoactive tea, ayahuasca, was consumed. Following three doses of the tea, the subjects showed strong and statistically significant increases of both EEG alpha (8-13Hz) and theta (4-8Hz) mean amplitudes compared to baseline while beta [...]
Lire la suitePlanche botanique de Cannabis sativa tirée du Nordisk familjebok, une encyclopédie suédoise publiée entre 1876 et 1957. Wikicommons Histoire. La résine de cannabis : remède miracle ou poison d’Orient ? David A Guba Jr.11 octobre 2019 XIXe siècle – France. Dans les années 1830, alors que la pandémie de choléra frappe l’Europe, le milieu médical français se passionne pour la résine de cannabis, parée de toutes les vertus. Nombreux sont ceux qui ont applaudi à l’annonce d’un début de réglementation prenant mieux en compte les enjeux de santé publique sur la consommation de cannabis en France. L’Agence nationale de sécurité du médicament a salué les [...]
Lire la suiteHallucinogen Persistent Perception Disorder Induced by New Psychoactive Substituted Phenethylamines; A Review with Illustrative Case Cornel N. Stanciu and Thomas M. Penders Current Psychiatry Reviews, 2016, Vol. 12, No. 2, 1-3. DOI: 10.2174/1573400512666160216234850 Abstract : Hallucinogen Persistent Perception Disorder (HPPD) is considered an “uncommon” disorder described in association with use of hallucinogens such as LSD, mescaline and psilocybin. Despite multiple mentions of persistence of visual disturbances reported by users on online forums, clinicians may not be aware of this complication. There have been few descriptions of HPPD in association with use of new psychoactive substances (such as 2C-E). Increasing use of these designer stimulants places [...]
Lire la suiteBook Review : The psychedelic religion of mystical consciousness, Rick Strassman William A. Richards Sacred Knowledge: Psychedelics and Religious Experiences Columbia University Press, New York, 2016, 244 pp. Hardback ISBN: 978-0-231-17406-0 Journal of Psychedelic Studies, 2018 Doi : 10.1556/2054.2018.003 With an extreme range of terms for psychedelic drugs – from “schizotoxic” to “entheogenic” – “psychedelic,” nonetheless remains the most salient one. These substances manifest or disclose aspects of the mind of those who take them as well as the mind of those who study them. Proponents for the innumerable terms for these drugs are all able to adduce supportive evidence. Necessarily, this evidence is a subjective experience, [...]
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