L’appel de 70 médecins, élus, économistes : « Pourquoi nous voulons légaliser le cannabis » La une de « l’Obs », du 20 au 26 juin 2019. (« L’Obs ») EXCLUSIF. Dénonçant la faillite de la politique de répression, 70 personnalités – Glucksmann, Jadot, Kouchner… – appellent à la légalisation du cannabis. Par L'Obs Publié le 19 juin 2019 à 06h30 En matière de cannabis, le tout-répressif ne marche pas. Alors sortons de cette politique coûteuse et inefficace. « L’Obs » lance avec plus de 70 économistes, médecins, politiques un appel à une légalisation encadrée. Objectifs prioritaires : la protection des mineurs, la sécurité [...]
Lire la suiteCannabis Use in Pregnancy. A Tale of 2 Concerns Michael Silverstein, MD, MPH1,2; Elizabeth A. Howell, MD, MPH3; Barry Zuckerman, MD1 JAMA. Published online June 18, 2019. doi:10.1001/jama.2019.8860 Original Investigation Association Between Self-reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes Daniel J. Corsi, PhD; Laura Walsh, MSc; Deborah Weiss, PhD; Helen Hsu, MD; Darine El-Chaar, MD; Steven Hawken, PhD; Deshayne B. Fell, PhD; Mark Walker, MD Research Letter Medical and Nonmedical Cannabis Use Among Pregnant Women in the United States Nora D. Volkow, MD; Beth Han, MD, PhD, MPH; Wilson M. Compton, MD, MPE; Elinore F. McCance-Katz, MD, PhD Full Text, https://jamanetwork.com/journals/jama/article-abstract/2736581 In an article in JAMA, Corsi and colleagues1 present the results of a retrospective cohort study of 661 617 women designed to assess associations between maternal cannabis use during pregnancy and adverse obstetrical and [...]
Lire la suiteRESEARCH LETTER Self-reported Medical and Non-medical Cannabis Use Among Pregnant Women in the United States JAMA, Published online June 18, 2019. doi: 10.1001/jama.2019.7982 Cannabis use increased among pregnantwomenin the United States from2002 to 2014.1 However, changes in cannabis use and frequency by trimester over time and national prevalence of medical cannabis use during pregnancy are unknown. Data fromtheNational Survey on Drug Use andHealth (NSDUH) were examined to address these knowledge gaps. Methods : Data were from women aged 12 to 44 years who participated in the 2002-2017 NSDUH, a representative survey of the US civilian, noninstitutionalized population.2 Collection of NSDUH data was approved [...]
Lire la suiteAssociation Between Self-reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes Daniel J. Corsi, PhD; LauraWalsh, MSc; DeborahWeiss, PhD; Helen Hsu, MD; Darine El-Chaar, MD; Steven Hawken, PhD; Deshayne B. Fell, PhD; MarkWalker,MD JAMA, Published online June 18, 2019. doi:10.1001/jama.2019.8734 Key Points Question Is there an association between prenatal cannabis exposure and maternal, perinatal, and neonatal outcomes? Findings In this retrospective cohort study that included 661 617 pregnancies and 9427 reported cannabis users, the rate of preterm birth among reported cannabis users was 12% vs 6% in nonusers, a statistically significant difference. Meaning Reported cannabis use in pregnancy was associated with significant increases in the rate of preterm [...]
Lire la suiteDiscriminative Stimulus Effects of Psychostimulants and Hallucinogens in S()-3,4-Methylene-dioxy-meth amphetamine (MDMA) and R()-MDMA Trained Mice K. S. Murnane, N. Murai, L. L. Howell, and W. E. Fantegrossi THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, Vol. 331, No. 2 Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics 156174/3525473 JPET 331:717–723, 2009 Preliminary findings from these experiments were previously presented as follows : Murnane K.S., 2008 Expérimentalement Biology Meeting; San Diego, CA. doi:10.1124/jpet.109.156174. ABSTRACT 3,4-Methylenedioxymethamphetamine (MDMA) is a substituted phenethylamine more commonly known as the drug of abuse “ecstasy.” The acute and persistent neurochemical effects of MDMA in the mice are distinct from those in [...]
Lire la suiteDream over life : Psychedelic terphenyl derivative induce hallucination via cannabinoid receptor 1 F.A. Fauzi, M.S. Goh, S.A.T.T. Johari, F. Hashim, M.F.N. Hassim The International Fundamentum Sciences Symposium 2018 IOP Publishing IOP Conf. Series: Materials Science and Engineering 440 (2018) 012045 doi:10.1088/1757-899X/440/1/012045 Abstract. For ages, natural psychedelic resources have been used by ancient tribes for religious inspiration. In modern medicine, these compounds were prescribed to relieve severe distress and depression on cancer patients. Despite medical benefit, abuse of these compounds have become prevalent in our modern society. These compounds usually interacted withcannabinoid receptor 1 (CNR1) on neuron cell causing hallucination, and on other cell-types. In this [...]
Lire la suiteDeconstructing Ecstasy : The Politics Of MDMA Research Charles S. Grob Addiction Research, 2000, 8, 6, 549-588 http://dx.doi.org/10.3109/16066350008998989 What is Ecstasy? Defined by the New Webster’s Dictionary as a state of intense overpowering emotion, a condition of exultation or mental rapture induced by beauty, music, artistic creation or the contemplation of the divine, ecstasy derives etymologically from the ancient Greek ekstasis, which means flight of the soul from the body. The anthropologist, Mircea Eliade, who explored the roots of religious experience in his book Shamanism: Archaic Techniques of Ecstasy, has described the function of this intense state of mind among aboriginal peoples. Select individuals [...]
Lire la suiteEpigenetic Effects of Cannabis Exposure Henrietta Szutorisz and Yasmin L. Hurd Biological Psychiatry, 2016, 79, 7, 586–594. doi:10.1016/j.biopsych.2015.09.014. Abstract The past decade has witnessed a number of societal and political changes that have raised critical questions about the long-term impact of marijuana (Cannabis sativa) that are especially important given the prevalence of its abuse and that potential long-term effects still largely lack scientific data. Disturbances of the epigenome have generally been hypothesized as the molecular machinery underlying the persistent, often tissue-specific transcriptional and behavioral effects of cannabinoids that have been observed within one’s lifetime and even into the subsequent generation. Here, we provide an overview [...]
Lire la suiteChanges in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5- HT2A receptor Katrin H. Preller, Joshua B. Burt, Jie Lisa Ji, Charles Schleifer, Brendan D. Adkinson, Philipp Stampfli, Erich Seifritz, Grega Repovs, John H. Krystal, John D. Murray, Franz X. Vollenweider, Alan Anticevic eLife, 2018, 7, e35082. DOI: https://doi.org/10.7554/eLife.35082.001 Abstract Background : Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-HT) and dopamine receptors. Despite the therapeutic and scientific interest in LSD, specific receptor contributions to its neurobiological effects remain unknown. Methods : We therefore conducted a double-blind, randomized, counterbalanced, cross-over study (ClinicalTrials.gov, NCT02451072) during which [...]
Lire la suiteDynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin Louis-David Lord, Paul Expert, Selen Atasoy, Leor Roseman, Kristina Rapuano, Renaud Lambiotte, David J. Nutt, Gustavo Deco, Robin L. Carhart-Harris, Morten L. Kringelbach, Joana Cabral, NeuroImage, 2019, 199, 127–142 https://doi.org/10.1016/j.neuroimage.2019.05.060 A B S T R A C T Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns (‘functional brain networks’), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous [...]
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