Marijuana Compounds : A Non-Conventional Therapeutic Approach to Epilepsy in Children Mariana Babayeva, Malka Fuzailov, Paulina Rozenfeld and Paramita Basu Journal of Addiction and Neuropharmacology, 2014, 1, 1, 002 Abstract Epilepsy in children is a complex disease, with a variety of distinct syndromes and many alternative treatment options. Even with a plethora of available treatment options, childhood epilepsies are commonly associated with seizures that are resistant to existing treatment methods. Treatment of pediatric epilepsy is challenging and requires more effective therapy to avoid short-term and longterm neurological disorders. Marijuana has been used to treat disease since ancient times. Marijuana ingredients Cannabidiol (CBD) and D9- Tetrahydrocannabinol (THC) [...]
Lire la suiteCannabis récréatif et politique: oui ou non, Emmanuel Macron est-il contre sa légalisation ? 19 juin 2019 jean-yves nau addictions, alcoolisme, Argent, législatif, Médecine, Polémique, Politique, Pouvoir, Risques (réduction des), tabagisme, Toxicomanies Étiquettes : L'Obs https://jeanyvesnau.com/2019/06/19/cannabis-recreatif-et-politique-oui-ou-non-emmanuel-macron-est-il-contre-sa-legalisation/ Bonjour Pour un peu le journaliste se lasserait. Des députés de quatre groupes politiques (dont certains macronistes) prônent désormais ouvertement une « légalisation contrôlée » du cannabis – et ce dans une proposition de loi transmise de mardi 18 juin à la presse. Ce texte sera officiellement déposé ce 19 juin. Signataires : François-Michel Lambert, Sylvia Pinel, Paul Molac, Jean-Michel Clément, Jeanine Dubié, Frédérique Dumas, François Pupponi (Libertés et territoires), Delphine Bagarry, Annie Chapelier, Hubert Julien-Laferrière, Pierre-Alain Raphan [...]
Lire la suiteAssociation Between Self-reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes Daniel J. Corsi, PhD; LauraWalsh, MSc; DeborahWeiss, PhD; Helen Hsu, MD; Darine El-Chaar, MD; Steven Hawken, PhD; Deshayne B. Fell, PhD; MarkWalker,MD JAMA, Published online June 18, 2019. doi:10.1001/jama.2019.8734 Key Points Question Is there an association between prenatal cannabis exposure and maternal, perinatal, and neonatal outcomes? Findings In this retrospective cohort study that included 661 617 pregnancies and 9427 reported cannabis users, the rate of preterm birth among reported cannabis users was 12% vs 6% in nonusers, a statistically significant difference. Meaning Reported cannabis use in pregnancy was associated with significant increases in the rate of preterm [...]
Lire la suiteThe Endocannabinoid System and its Modulation by Phytocannabinoids Vincenzo Di Marzo & Fabiana Piscitelli Neurotherapeutics, 2015, 12, 692–698 DOI 10.1007/s13311-015-0374-6 Abstract : The endocannabinoid system is currently defined as the ensemble of the two 7-transmembrane-domain and G protein-coupled receptors for Δ9-tetrahydrocannabinol (but not for most other plant cannabinoids or phytocannabinoids)—cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R); their two most studied endogenous ligands, the “endocannabinoids” N-arachidonoyl-ethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG); and the enzymes responsible for endocannabinoid metabolism. However, anandamide and 2-AG, and also the phytocannabinoids, have more molecular targets than just CB1R and CB2R. Furthermore, the endocannabinoids, like most other lipid mediators, have more [...]
Lire la suiteThe Cannabis Conundrum : Thinking Outside the THC Box Sarah L. Hagerty, Sophie L. York Williams, Vijay A. Mittal, and Kent E. Hutchison The Journal of Clinical Pharmacology, 2015, 55, 8, 839–841 DOI: 10.1002/jcph.511 Keywords : cannabis, cannabinoids, D9-tetrahydrocannabinol (THC), cannabidiol (CBD), psychosis Despite nationwide movements to legalize and regulate cannabis, our understanding of its effects on human health is tenuous at best. Developing a solid evidence base regarding the health effects of cannabis is imperative given the momentum for legalization and the demand for sound regulatory practices. This present commentary will identify limitations with respect to previous research on cannabis, discuss the genesis and implications [...]
Lire la suiteAu Canada, le cannabis comestible sera disponible à la vente en décembre Le pays avait été en octobre le deuxième au monde, après l’Uruguay, à autoriser la vente libre de marijuana. Des règles strictes devront être respectées pour limiter l’attractivité des produits à base de cannabis auprès des jeunes. Le Monde avec AFP Publié , 15 juin 2019, aujourd’hui à 00h21, mis à jour à 11h11 Des cookies au cannabis dans un magasin éphèmère de Rome, en Italie, le 6 juin. ANDREW MEDICHINI / AP Des produits comestibles à base de cannabis seront vendus au Canada dès la mi-décembre, a annoncé, [...]
Lire la suiteThe neuropsychopharmacology of cannabis : A review of human imaging studies Michael A.P. Bloomfield, Chandni Hindocha, Sebastian F. Green, Matthew B.Wall, Rachel Lees, Katherine Petrilli, Harry Costello, M. Olabisi Ogunbiyi, Matthijs G. Bossong, Tom P. Freeman Pharmacology & Therapeutics, 2019, 195, 132-161 doi : 10.1016/j.pharmthera.2018.10.006 a b s t r a c t The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Δ9-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, [...]
Lire la suiteRegular cannabis use is associated with altered activation of central executive and default mode networks even after prolonged abstinence in adolescent users : Results from a complementary meta-analysis Grace Blest-Hopley, Vincent Giampietro and Sagnik Bhattacharyya Neuroscience & Biobehavioral Reviews, 2019, 96, 45–55. doi: 10.1016/j.neubiorev.2018.10.026: 10.1016/j.neubiorev.2018.10.026 PMCID: PMC6331661 PMID: 30395923 Abstract Whether the effects of cannabis use on brain function persist or recover following abstinence remains unclear. Therefore, using meta-analytic techniques, we examined whether functional alterations measured using fMRI persist in cannabis users abstinent for over 25 days (or 600 h) as evidence suggests that the effects on cognitive performance no longer persist beyond this period. Systematic literature search [...]
Lire la suiteDoes Cannabis Composition Matter? Differential Effects of Delta-9-tetrahydrocannabinol and Cannabidiol on Human Cognition Marco Colizzi & Sagnik Bhattacharyya Current Addiction Reports, 2017, 4, 62–74 DOI 10.1007/s40429-017-0142-2 Abstract Purpose of Review : The lack of clarity about the effect of cannabis use on cognition may be attributable to the considerable heterogeneity among studies in terms of cannabis composition. This article selectively reviews studies examining the distinctive effects of cannabinoids on human cognition, particularly those of delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Recent Findings : Research indicates that Δ9-THC administration acutely impairs cognition, particularly memory and emotional processing. Limited evidence suggests that CBD administration might improve cognition in cannabis [...]
Lire la suiteCannabis Use Disorder During the Perinatal Period Martha L. Velez, Chloe J. Jordan, and Lauren M. Jansson Chapter 17, in : I. D. Montoya, S. R. B. Weiss (eds.), Cannabis Use Disorders, 2019, © Springer Nature Switzerland AG 2019 177 https://doi.org/10.1007/978-3-319-90365-1_17 Introduction Cannabis use in the perinatal period has been increasing in recent years, coincident with increasing legalization in the USA for medical or recreational purposes [1]. Marijuana is the most commonly used illicit drug during pregnancy [2], and among some populations, it is used more frequently than tobacco [3, 4]. Although the prevalence of cannabis use during pregnancy is difficult to ascertain with accuracy, [...]
Lire la suite