Does Cannabis Composition Matter? Differential Effects of Delta-9-tetrahydrocannabinol and Cannabidiol on Human Cognition Marco Colizzi & Sagnik Bhattacharyya Current Addiction Reports, 2017, 4, 62–74 DOI 10.1007/s40429-017-0142-2 Abstract Purpose of Review : The lack of clarity about the effect of cannabis use on cognition may be attributable to the considerable heterogeneity among studies in terms of cannabis composition. This article selectively reviews studies examining the distinctive effects of cannabinoids on human cognition, particularly those of delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Recent Findings : Research indicates that Δ9-THC administration acutely impairs cognition, particularly memory and emotional processing. Limited evidence suggests that CBD administration might improve cognition in cannabis [...]
Lire la suiteCannabis Chemovar Nomenclature Misrepresents Chemical and Genetic Diversity; Survey of Variations in Chemical Profiles and Genetic Markers in Nevada Medical Cannabis Samples Ulrich Reimann-Philipp, Mark Speck, Cindy Orser, Steve Johnson, Aaron Hilyard, Helen Turner, Alexander J. Stokes, and Andrea L. Small-Howard Cannabis and Cannabinoid Research, Volume X, Number X, 2019 Mary Ann Liebert, Inc. DOI: 10.1089/can.2018.0063 Abstract Introduction : Medical cannabis patients receive clinical benefits from the secondary metabolites of the plant, which contain a variety of cannabinoids and terpenoids in combinations that can be used to classify the chemovars. State-regulated medical cannabis programs rely on breeder-reported ‘‘strain’’ names both within diversion control systems and to [...]
Lire la suiteThe Effect of Light Spectrum on the Morphology and Cannabinoid Content of Cannabis sativa L. Gianmaria Magagnini, Gianpaolo Grassi, Stiina Kotiranta Medical Cannabis and Cannabinoids, 2018, 1, 19–27 DOI : 10.1159/000489030 Abstract Cannabis sativa L. flowers are the main source of Δ-9- tetrahydrocannabinol (THC) used in medicine. One of the most important growth factors in cannabis cultivation is light; light quality, light intensity, and photoperiod play a big role in a successful growth protocol. The aim of the present study was to examine the effect of 3 different light sources on morphology and cannabinoid production. Cannabis clones were grown under 3 different light spectra, namely [...]
Lire la suiteExtractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses Melissa M. Lewis-Bakker, Yi Yang, Rupali Vyawahare, and Lakshmi P. Kotra Cannabis and Cannabinoid Research, 2019, Volume X, Number X, 2019 Mary Ann Liebert, Inc. DOI: 10.1089/can.2018.0067 Abstract Introduction : Phytocannabinoids, characteristic compounds produced by medical cannabis, interact with cannabinoid (CB) receptors (CB1 and CB2) as well as other receptor systems to exhibit their corresponding pharmacological effects. In their natural form, CBs such as D9-tetrahydrocannabinolic acid and cannabidiolic acid are inactive at these receptors, while their decarboxylated forms (D9 tetrahydrocannabinol and cannabidiol, respectively) are potent ligands at CB receptors. Thus, extraction and [...]
Lire la suiteThe Association between Cannabis Product Characteristics and Symptom Relief Sarah S. STITH, Jacob M. VIGIL, Franco BROCKELMAN, Keenan KEELING, Branden HALL Scientific Reports - Nature, 2019, 9, 2712. Published online 2019 Feb 25. doi: 10.1038/s41598-019-39462-1 PMCID: PMC6389973 PMID: 30804402 Abstract Federal barriers and logistical challenges have hindered measurement of the real time effects from the types of cannabis products used medically by millions of patients in vivo. Between 06/06/2016 and 03/05/2018, 3,341 people completed 19,910 self- administrated cannabis sessions using the mobile device software, ReleafApp to record: type of cannabis product (dried whole natural Cannabis flower, concentrate, edible, tincture, topical), combustion method (joint, pipe, vaporization), Cannabis [...]
Lire la suiteVariétés de Cannabis: Par Docteur Ethan Russo http://www.cannabis-med.org/index.php?tpl=faq&red=faqlist&id=172&lng=fr Les consommateurs de cannabis ont souvent indiqué que les différentes variétés de cannabis produisent des effets variables, que se soit concernant les effets psychoactifs ou les bénéfices thérapeutiques. Les variétés sont généralement désignées comme étant soit Sativa, soit Indica, soit hybrides. Or, ces noms, d’un point de vue commercial, prêtent à confusion. Pour cette raison, la communauté scientifique s’est concentrée sur le Tétrahydrocannabinol (THC) qu’elle considérait comme la principale variable et la seule d’importance. En parallèle, jusqu’à très récemment, les croisements sélectifs des variétés de cannabis, destiné à l’usage récréatif ou à l’usage thérapeutique, [...]
Lire la suiteThe Anti-Inflammatory Properties of Terpenoids from Cannabis Ruth Gallily, Zhannah Yekhtin, and Lumı´r Ondrˇej Hanusˇ Cannabis and Cannabinoid Research, 3, 1, 2018, 282-290. Doi : 10.1089/can.2018.0014 Abstract : Introduction : Cannabinoids are well known to have anti-inflammatory effects in mammalians; however, the Cannabis plant also contains other compounds such as terpenoids, whose biological effects have not yet been characterized. The aim of this study was to compare the anti-inflammatory properties of terpenoids with those of cannabidiol (CBD). Materials and Methods : Essential oils prepared from three monoecious nonpsychoactive chemotypes of Cannabis were analyzed for their terpenoid content and subsequently studied pharmacologically for their anti-inflammatory properties in [...]
Lire la suiteCannabis - from cultivar to chemovar A. Hazekamp and J. T. Fischedick Drug Testing and Analysis, 2012, (wileyonlinelibrary.com) DOI 10.1002/dta.407, Copyright © 2012 John Wiley & Sons, Ltd. Abstract : The medicinal use of Cannabis is increasing as countries worldwide are setting up official programs to provide patients with access to safe sources of medicinal-grade Cannabis. An important question that remains to be answered is which of the many varieties of Cannabis should be made available for medicinal use. Drug varieties of Cannabis are commonly distinguished through the use of popular names, with a major distinction being made between Indica and Sativa types. Although more than [...]
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