Marijuana Use Linked to Stroke, Arrhythmia in Young People Sue Hughes Medscape - Nov 12, 2019 https://www.medscape.com/viewarticle/921116?nlid=132614_2052&src=WNL_mdplsnews_191115_mscpedit_psyc&uac=292598PZ&spon=12&impID=2168195&faf=1019 Use of marijuana is linked to a higher risk of stroke and hospitalization for cardiac arrhythmia in young people, two new studies suggest. Both studies will be presented at this weekend's American Heart Association (AHA) Scientific Sessions 2019 in Philadelphia. In the observational stroke study, young adults with recent marijuana use had almost twice the risk compared with non-users of having had a stroke, and the risk increased further among frequent marijuana users. The risk of having had a stroke was even higher — three times that of non-users — in frequent [...]
Lire la suiteComment le cannabis peut favoriser les troubles psychotiques : conséquences, dépistage et prise en charge Alain Dervaux L’Information Psychiatrique, 2019, 95, (8), 672-678 * Travail présenté aux 37es journées de la Société de l’Information Psychiatrique, Antibes, 4-6 octobre 2018. Résumé Les relations complexes entre cannabis et psychoses ont fait l’objet de nombreux travaux depuis une vingtaine d’années. La consommation de cannabis peut s’accompagner de symptômes psychotiques chez certains sujets (jusqu’à 15 % des consommateurs) qui disparaissent avec l’élimination du -9-THC de l’organisme. Elle peut aussi augmenter par deux le risque de troubles psychotiques, notamment de schizophrénie. Le risque est d’autant plus élevé que la consommation de cannabis [...]
Lire la suiteComparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ9-Tetrahydrocannabinol Chris S. Breivogel, Jacob R. Wells, Amreen Jonas, Artik H. Mistry, Morgan L. Gravley, Rajul M. Patel, Brianna E. Whithorn, and Bonnie M. Brenseke Cannabis and Cannabinoid Research, 2019, Volume X, Number X DOI: 10.1089/can.2019.0003 Abstract Introduction : Synthetic cannabinoids (SCs) are commonly found in preparations used as recreational drugs. Although severe adverse health effects are not generally associated with cannabis use, a rising number of studies document seizures and even death after SC use. In this study, a mouse model is used to investigate the hypothesis that SCs are more [...]
Lire la suiteCannabinoids, Endocannabinoids and Cancer Daniel J. Hermanson and Lawrence J. Marnett Cancer Metastasis Reviews, 2011, 30, (3-4), 599–612. doi:10.1007/s10555-011-9318-8. 1. Introduction 1.1 Cannabinoid Function Endocannabinoids are bioactive lipids that have a range of interesting activities mediated by two G-protein-coupled receptors (CB1 and CB2) and other putative targets [1-3]. The CB1 receptor is present in the central nervous system and mediates the psychotropic effects of exogenous cannabinoids such as Δ9-tetrahydrocannabinol (THC), the active component of marijuana. In the brain, endocannabinoids and cannabinoids combine with CB1 cannabinoid receptors on axon terminals and regulate ion channel activity and neurotransmitter release [4]. Binding to the CB1 receptor is responsible for [...]
Lire la suiteLegal highs : staying on top of the flood of novel psychoactive substances David Baumeister, Luis M. Tojo and Derek K. Tracy Therapeutic Advances in Psychopharmacology, 2015, Vol. 5, (2), 97–132 DOI: 10.1177/2045125314559539 Abstract : There has been growing clinical, public, and media awareness and concern about the availability and potential harmfulness of so-called ‘legal highs’, which are more appropriately called new or novel psychoactive substances (NPS). A cat-and-mouse process has emerged wherein unknown chemists and laboratories are producing new, and as yet nonproscribed, compounds for human consumption; and as soon as they are banned, which they inevitably are, slightly modified analogues are produced to [...]
Lire la suiteThe Relevance of Sex in the Association of Synthetic Cannabinoid Use With Psychosis and Agitation in an Inpatient Population Anahita Bassir Nia, MD‡; Claire L. Mann, BA; Sharron Spriggs, MA; Daniel R. DeFrancisco, MD; Steven Carbonaro, MD; Lyla Parvez, MA; Igor I. Galynker, MD, PhD; Charles A. Perkel, MD; and Yasmin L. Hurd, PhD Journal of Clinical Psychiatry, 2019, 80, (4), 18m12539 https://doi.org/10.4088/JCP.18m12539 Background : Current evidence suggests that women are more sensitive to the effects of cannabinoids. The aim of this study was to investigate the relevance of sex in the association of synthetic cannabinoid (SC) use with psychosis and agitation. Methods : A [...]
Lire la suiteThe effects of Δ9-tetrahydrocannabinol on the dopamine system Michael A P Bloomfield, Abhishekh H Ashok, Nora D Volkow, and Oliver D Howes Nature, 2016, 539, 7629, 369–377. doi : 10.1038/nature20153. Preface Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, is a pressing concern to global mental health. Patterns of use are changing drastically due to legalisation, availability of synthetic analogues (‘spice’), cannavaping and aggrandizements in the purported therapeutic effects of cannabis. Many of THC’s reinforcing effects are mediated by the dopamine system. Due to complex cannabinoid-dopamine interactions there is conflicting evidence from human and animal research fields. Acute THC causes increased dopamine release and neuron [...]
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