Les Phyto-cannabinoïdes Non-psychotropes* : Les nouvelles Opportunités d'une plante ancienne.(*NdT : non-stupéfiants) Angelo A. Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo and Raphael Mechoulam Trends in Pharmacological Sciences - CELL Press, 2009, 30, 10, 515-27. doi: 10.1016/j.tips.2009.07.006. Le Δ9-tetrahydrocannabinol (Δ9THC) se lie aux récepteurs endocannabinoïdes (CB1 et CB2) qui sont activés par les cannabinoïdes endogènes (endocannabinoïdes) et qui sont impliqués dans une large gamme de processus physiopathologiques (exemple: modulation de la libération de neurotransmetteurs, régulation de la perception de la douleur, régulation des fonctions cardiovasculaires, gastro-intestinales et hépatiques). Les effets psychotropes bien connus du Δ9THC qui sont véhiculés par l'activation des récepteurs CB1 [...]
Lire la suiteQu’est-ce que le cannabinol ? Les CBN est le Cannabinoïde responsable d’un meilleur sommeil Aujourd’hui , les capacités de développement et de recherche dans le secteur du cannabis reconnaisse que le facteur responsable du sommeil est le cannabinoïde communément appelé le CBN. Il vous reste quelques fleurs de canna dans une vieille boite ? Certes, il se pourrait qu’il soit beaucoup moins fort en THC. Mais il a de forte chance que votre contenu est chargé en CBN Qu’est ce que le CBN ? Le CBN se forme à partir du THC ” rance ” ou ” pas frais ”. Il a des avantages [...]
Lire la suiteThe Anti-Inflammatory Properties of Terpenoids from Cannabis Ruth Gallily, Zhannah Yekhtin, and Lumı´r Ondrˇej Hanusˇ Cannabis and Cannabinoid Research, 3, 1, 2018, 282-290. Doi : 10.1089/can.2018.0014 Abstract : Introduction : Cannabinoids are well known to have anti-inflammatory effects in mammalians; however, the Cannabis plant also contains other compounds such as terpenoids, whose biological effects have not yet been characterized. The aim of this study was to compare the anti-inflammatory properties of terpenoids with those of cannabidiol (CBD). Materials and Methods : Essential oils prepared from three monoecious nonpsychoactive chemotypes of Cannabis were analyzed for their terpenoid content and subsequently studied pharmacologically for their anti-inflammatory properties in [...]
Lire la suiteAdenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus : Cannabidiol Blunts Δ9Tetrahydrocannabinol-Induced Cognitive Impairment Ester Aso, Víctor Fernández-Dueñas, Marc López-Cano, Jaume Taura, Masahiko Watanabe, Isidre Ferrer, Rafael Luján, Francisco Ciruela, Ester Aso Molecular Neurobiology, First Online: 04 January 2019, pp 1-10. C : Springer Nature Switzerland AG Abstract : At present, clinical interest in the plant-derived cannabinoid compound cannabidiol (CBD) is rising exponentially, since it displays multiple therapeutic properties. In addition, CBD can counteract the undesirable effects of the psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) that hinder clinical development of cannabis-based therapies. Despite this attention, the mechanisms of CBD action and its interaction with Δ9-THC are still not completely elucidated. Here, by combining in vivo [...]
Lire la suiteThe Role of CB2 Receptor in the Recovery of Mice after Traumatic Brain Injury Lital MAJID, Sami HEYMAN, Merav ELGALI ... Esther SHOHAMI et al. Journal of Neurotrauma, Nov 2018, 36, 1-11 DOI: 10.1089/neu.2018.6063 Abstract : Cannabis is one of the most widely used plant drugs in the world today. In spite of the large number of scientific reports on medical marijuana, there still exists much controversy surrounding its use and the potential for abuse due to the undesirable psychotropic effects. However, recent developments in medicinal chemistry of novel non-psychoactive synthetic cannabinoids have indicated that it is possible to separate some of the therapeutic effects [...]
Lire la suiteMarijuana, National Institute on Drug Abuse (NIDA), June 2018 Table of Contents Marijuana Letter From the Director What is marijuana? What is the scope of marijuana use in the United States? What are marijuana effects? How does marijuana produce its effects? Does marijuana use affect driving? Is marijuana addictive? What are marijuana's long-term effects on the brain? Is marijuana a gateway drug? How does marijuana use affect school, work, and social life? Is there a link between marijuana use and psychiatric disorders? What are marijuana's effects on lung health? What are marijuana’s effects on other aspects of physical health? Is marijuana safe and effective as medicine? What are the effects of secondhand exposure to marijuana smoke? Can marijuana [...]
Lire la suiteThe Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis : no "Strain", no Gain Ethan B. Russo, Frontiers in Plant Science, 2019, Volume 9, Article 1969, 1-8. doi : 10.3389/fpls.2018.01969 The topic of Cannabis curries controversy in every sphere of influence, whether politics, pharmacology, applied therapeutics or even botanical taxonomy. Debate as to the speciation of Cannabis, or a lack thereof, has swirled for more than 250 years. Because all Cannabis types are eminently capable of cross-breeding to produce fertile progeny, it is unlikely that any clear winner will emerge between the “lumpers” vs. “splitters” in this taxonomical debate. This is [...]
Lire la suiteREVIEW-THEMED ISSUE Cannabis, from plant to pill Pr Christopher GROF, British Journal of Clinical Pharmacology, 2018, 84, 2463-2467 Correspondence Professor Christopher P. L. Grof, School of Environmental and Life Sciences, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. Tel.: + 61 2 49215858; Fax: +61 2 4921 5361; 1 Centre for Plant Science, School of Environmental and Life Sciences, University of Newcastle, Newcastle, NSW 2308, Australia and 2 The Australian Centre for Cannabinoid Clinical and Research Excellence Hunter Medical Research Institute, Locked Bag 1000, New Lambton, NSW2305, Australia Keywords : cannabinoids, cannabis, flos, flower, terpenoids The therapeutic application of cannabis is attracting substantial public and clinical interest. [...]
Lire la suiteAntidépresseur-like effect induced by Cannabidiol is dependent on brain serotonin levels. A.J. Sales, C. C. Crestani, F. S. Guimaraes, S. R.L. Joca, Progress in Neuropsychopharmacology & Biological Psychiatry, 2018 Aug 30; 86: 255-261. Doi: 10.1016/j.pnpbp.2018.06.002 https://www.ncbi.nlm.nih.gov/pubmed/29885468 PMID : 29885468 Abstract Cannabidiol (CBD) is a compound of Cannabis sativa with relevant therapeutic potential in several neuropsychiatric disorders including depression. CBD treatment has shown significant antidepressant-like effects in different rodent preclinical models. However, the mechanisms involved in CBD-induced antidepressant effects are still poorly understood. Therefore, this work aimed at investigating the participation of serotonin (5-HT) and/or noradrenaline (NA) in CBD-induced antidepressant-like effects in [...]
Lire la suiteCannabis and the Anxiety of Fragmentation - A Systems Approach for Finding an Anxiolytic Cannabis Chemotype, B. S. Kamal, F. Kamal, D. E. Lantela, Frontiers in Neuroscience, 2018, 12, article 730. https://doi.org/10.3389/fnins.2018.00730 Abstract : Cannabis sativa is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis as highly effective overall for treating anxiety with an average score of 8.03 on a Likert scale of 0 to 10 (0 = not effective, [...]
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