Catégorie : Ressources Documentaires

3,4-Methylenedioxymethamphetamine assisted psychotherapy for treatment of chronic posttraumatic stress disorder : A randomized phase 2 controlled trial, Marcela Ot’alora G et al., 2018

3,4-Methylenedioxymethamphetamine assisted psychotherapy for treatment of chronic posttraumatic stress disorder : A randomized phase 2 controlled trial Marcela Ot’alora G, Jim Grigsby, Bruce Poulter1, Joseph W Van Derveer III, Sara Gael Giron, Lisa Jerome, Allison A Feduccia, Scott Hamilton, Berra Yazar-Klosinski, Amy Emerson, Michael C Mithoefer and Rick Doblin Journal of Psychopharmacology, 2018, 1-13 Doi : 10.1177/0269881118806297   Abstract Background : Posttraumatic stress disorder often does not resolve after conventional psychotherapies or pharmacotherapies. Pilot studies have reported that 3,4-methylenedioxymethamphetamine (MDMA) combined with psychotherapy reduces posttraumatic stress disorder symptoms. Aims : This pilot dose response trial assessed efficacy and safety of MDMA-assisted psychotherapy across multiple therapy teams. Methods : [...]

Lire la suite

Chapter : The endocannabinoid system in Fragile X Syndrome, Henry G. S. Martin et al., 2017

Chapter : The endocannabinoid system in Fragile X Syndrome Henry G. S. Martin, Daniela Neuhofer and Olivier J.J. Manzoni Fragile X Syndrome : From Genetics to Targeted Treatment, 2017, Pages 241-259 DOI: 10.1016/B978-0-12-804461-2.00012-3 Addresses: INSERM U901, INMED and UMR S901, Aix-Marseille University Marseille 13009, France. Abstract : Endocannabinoid signaling is a finely tuned system of molecules and lipid messengers that modulate neurotransmission in a rapid and sustained manner at many central synapses. The endocannabinoid system is important for many brain activities, but is also implicated in several neuropsychiatric disorders. In this chapter we discuss emerging evidence of dysfunction in endocannabinoid signaling in Fragile X Syndrome from the Fmr1 knockout mouse model. [...]

Lire la suite

Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol, Ruth Gallily et al.,

Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol Ruth Gallily, Zhannah Yekhtin, Lumír Ondřej Hanuš Pharmacology & Pharmacy, 2015, 6, 75-85 http://dx.doi.org/10.4236/pp.2015.62010 Abstract : Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti inflammatory and anti‐anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell‐shaped dose‐response was observed, which limits its clinical use. In the present study, we have studied in mice the anti‐inflammatory and anti nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched [...]

Lire la suite

Legalizing and Regulating Marijuana in Canada: Review of Potential Economic, Social, and Health Impacts, Mohammad Hajizadeh, 2016

Legalizing and Regulating Marijuana in Canada: Review of Potential Economic, Social, and Health Impacts Mohammad Hajizadeh International Journal of Health Policy and Management, 2016, 5, 8, 453–456. doi:10.15171/ijhpm.2016.63 Abstract : Notwithstanding a century of prohibition, marijuana is the most widely used illicit substance in Canada. Due to the growing public acceptance of recreational marijuana use and ineffectiveness of the existing control system in Canada, the issue surrounding legalizing this illicit drug has received considerable public and political attentions in recent years. Consequently, the newly elected Liberal Government has formally announced that Canada will introduce legislation in the spring of 2017 to start legalizing and regulating [...]

Lire la suite

Cannabis legalization in Canada: how might ‘strict’ regulation impact youth ?, Tara Marie Watson & Patricia G. Erickson, 2018

Cannabis legalization in Canada: how might ‘strict’ regulation impact youth? Tara Marie Watson & Patricia G. Erickson DRUGS: EDUCATION, PREVENTION AND POLICY, 2018 https://doi.org/10.1080/09687637.2018.1482258   EDITORIAL Cannabis legalization in Canada: how might ‘strict’ regulation impact youth? Canada is on course to become, in October 2018, the second country in the world, after Uruguay, to federally legalize cannabis for recreational use. Prime Minister Justin Trudeau’s Liberal government has set out to achieve several objectives with this major drug policy reform, including ‘[to] Protect young Canadians by keeping marijuana out of the hands of children and youth’ (Government of Canada, 2016). While protecting the health and safety of [...]

Lire la suite

Cannabis legalization in the provinces and territories : missing opportunities to effectively educate youth ?Tara Marie Watson et al., 2019

Cannabis legalization in the provinces and territories : missing opportunities to effectively educate youth ? Tara Marie Watson, Jenna Valleriani, Elaine Hyshka & Sergio Rueda Canadian Journal of Public Health, 2019 https://doi.org/10.17269/s41997-019-00209-0 Abstract Cannabis is now legal in Canada, yet important questions remain regarding how the provinces and territories are approaching cannabis education and messaging aimed at youth. Although widespread education and awareness campaigns are long considered cornerstones of substance use and related harm prevention, there is limited evidence to support the effectiveness of such campaigns. We continue to see examples of cannabis-related messaging that focus on risk and harm and often adopt a narrow [...]

Lire la suite

A Cross-Sectional Survey of Medical Cannabis Users : Patterns of Use and Perceived Efficacy, Michelle Sexton et al.,

A Cross-Sectional Survey of Medical Cannabis Users : Patterns of Use and Perceived Efficacy Michelle Sexton, Carrie Cuttler, John S. Finnell, and Laurie K. Mischley Cannabis and Cannabinoid Research, 2016, Volume 1.1, 131-138 DOI: 10.1089/can.2016.0007 Abstract Background: The political climate around Cannabis as a medicine is rapidly changing. Legislators are adopting policies regarding appropriate medical applications, while the paucity of research may make policy decisions around conditions for which Cannabis is an effective medicine difficult. Methods: An anonymous online survey was developed to query medical Cannabis users about the conditions they use Cannabis to treat, their use patterns, perception of efficacy, and physical and mental health. [...]

Lire la suite

Sex Differences in Cannabis Use and Effects: A Cross-Sectional Survey of Cannabis Users, Carrie Cuttler et al., 2016

Sex Differences in Cannabis Use and Effects: A Cross-Sectional Survey of Cannabis Users Carrie Cuttler, Laurie K. Mischley, and Michelle Sexton Cannabis and Cannabinoid Research, 2016, 1, 1, 166-175 DOI : 10.1089/can.2016.0010 Abstract Introduction : Despite known sex differences in the endocannabinoid system of animals, little attention has been paid to sex differences in human's cannabis use patterns and effects. The purpose of the present study was to examine sex differences in cannabis use patterns and effects in a large sample of recreational and medical cannabis users. Methods : A large sample (n=2374) of cannabis users completed an anonymous, online survey that assessed their cannabis use [...]

Lire la suite

Cannabinoid Actions on Neural Stem Cells : Implications for Pathophysiology, Rui S. Rodrigues et al., 2019

Cannabinoid Actions on Neural Stem Cells : Implications for Pathophysiology Rui S. Rodrigues, Diogo M. Lourenço, Sara L. Paulo, Joana M. Mateus, Miguel F. Ferreira, Francisco M. Mouro, João B. Moreira, Filipa F. Ribeiro, Ana M. Sebastião and Sara Xapelli Molecules, 2019, 24, 1350, 59 pp. Abstract : With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect [...]

Lire la suite

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid, Ewa Kozela et al., 2017

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid. Ewa Kozela, Ana Juknat, and Zvi Vogel International Journal of Molecular Sciences, 2017, 18, 1669, 20 pp. doi:10.3390/ijms18081669 PMID : 28788104   PMCID : PMC5578059 Abstract The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their precise regulation is still far from understood, although several candidate molecules/systems arise as promising targets for astrocyte-mediated neuroregulation and/or neuroprotection. The cannabinoid system and its ligands have been shown to interact and affect activities of astrocytes. Cannabidiol (CBD) is the main [...]

Lire la suite