Catégorie : Publications

Association Between Marijuana Use and Adverse Obstetrical and Neonatal Outcomes, C.R. Warshak, J. Regan et al., 2015

Association Between Marijuana Use and Adverse Obstetrical and Neonatal Outcomes CR Warshak; J Regan; B Moore; K Magner; S Kritzer; J Van Hook Journal of Perinatology, 2015, 35, 12, 991-995. PMID : 26401751 DOI : 10.1038/jp.2015.120 Abstract and Introduction Abstract Objective: To evaluate associations between marijuana exposure and adverse outcomes excluding women with polysubstance abuse and stratifying for concurrent maternal tobacco use. Study Design: We performed a retrospective cohort study evaluating various obstetrical and neonatal outcomes including: preterm delivery, pre-eclampsia, gestational diabetes, cesarean delivery, fetal growth restriction, a composite which included stillbirth or neonatal intensive care unit admission, and perinatal mortality. We stratified study groups [...]

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Cannabis For Cancer-Related Symptoms (CAFCARS), ClinicalTrials.gov Identifier : NCT03948074, mai 2019

Cannabis For Cancer-Related Symptoms (CAFCARS) https://clinicaltrials.gov/ct2/show/NCT03948074?recrs=abdf&cond=cannabis&draw=2&rank=98 ClinicalTrials.gov Identifier: NCT03948074 Recruitment Status : Not yet recruiting First Posted : May 13, 2019 Last Update Posted : May 13, 2019 See Contacts and Locations Sponsor: Pippa Hawley Information provided by (Responsible Party): Pippa Hawley, British Columbia Cancer Agency Study Description Brief Summary: Clinical evidence is urgently needed to be able to advise patients on which cannabis-based products to take, or to avoid, in managing cancer-related symptoms. This trial was therefore designed to determine which cannabis extract combination (High THC-Low CBD, Low THC-High CBD, or Equal amounts of THC and CBD) is most effective at treating cancer related symptoms for each [...]

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Marijuana and fertility, Sara Ilnitsky & Stan Van Uum, 2019

Marijuana and fertility Sara Ilnitsky MD, Stan Van Uum MD Canadian Medical Association Journal, 2019 June 10, 191, 23, E638. doi : 10.1503/cmaj.181577 CMAJ Podcasts: author interview at https://soundcloud.com/cmajpodcasts/181577-five   1 Tetrahydrocannabinol acts on the endocannabinoid system, which is ubiquitous in reproductive tissues Tetrahydrocannabinol, the active ingredient in marijuana, is a lipophilic compound with a prolonged half-life of 20–36 hours.1 Tetrahydrocannabinol activates the cannabinoid receptors, which are part of the endogenous endocannabinoid system. This system is found in the hypothalamus, pituitary and internal reproductive organs in both sexes.2,3 2 Marijuana use can decrease sperm count Smoking marijuana more than once weekly in the preceding 3 months (n = 130/1215) [...]

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The Endocannabinoid System : A New Treatment Target for Obsessive Compulsive Disorder ?, Reilly R. Kayser et al., 2019

The Endocannabinoid System : A New Treatment Target for Obsessive Compulsive Disorder ? Reilly R. Kayser, Ivar Snorrason, Margaret Haney, Francis S. Lee, and H. Blair Simpson1 Cannabis and Cannabinoid Research, 2019, Volume 4, Number 2, Mary Ann Liebert, Inc. DOI: 10.1089/can.2018.0049   Abstract Introduction : Obsessive-compulsive disorder (OCD) is a disabling illness that is associated with significant functional impairment. Although evidence-based pharmacotherapies exist, currently available medications are ineffective in some patients and may cause intolerable side effects in others. There is an urgent need for new treatments. Discussion : A growing body of basic and clinical research has showed that the endocannabinoid system(ECS) plays a role in [...]

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Cannabis Companies Push F.D.A. to Ease Rules on CBD Products, Sheila Kaplan, The New York Time, May 31, 2019

Cannabis Companies Push F.D.A. to Ease Rules on CBD Products By Sheila Kaplan The New York Time, May 31, 2019 CBD products have exploded in recent years, and are so numerous and varied as to include cheese pizza and fruit smoothies, like at this restaurant in Fort Lauderdale, Fla.CreditJennifer Lett/South Florida Sun-Sentinel, via Associated Press Image CBD products have exploded in recent years, and are so numerous and varied as to include cheese pizza and fruit smoothies, like at this restaurant in Fort Lauderdale, Fla.CreditCreditJennifer Lett/South Florida Sun-Sentinel, via Associated Press     WASHINGTON — It was Hempy Pet CBD Soft Chews, Mile High Labs and Women Grow, [...]

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Measuring Disturbance of the Endocannabinoid System in Psychosis. A Systematic Review and Meta-analysis, Amadeo Minichino et al., 2019

Measuring Disturbance of the Endocannabinoid System in Psychosis. A Systematic Review and Meta-analysis Amedeo Minichino, MD1; Morwenna Senior, MD1; Natascia Brondino, PhD2; et al Sam H Zhang, BA1; Beata R Godwlewska, PhD1; Philip W.J Burnet, PhD1; Andrea Cipriani, PhD1,3; Belinda R. Lennox, DM1 JAMA Psychiatry, Published online June 5, 2019. doi:10.1001/jamapsychiatry.2019.0970 Editorial : Pathophysiology of Endocannabinoid Signaling in Schizophrenia David W. Volk, MD, PhD; David A. Lewis, MD   Question  Is the endocannabinoid system abnormal in people with psychosis? Findings  In this systematic review and meta-analysis of 18 studies, a higher tone of the endocannabinoid system was observed in people with psychosis, a finding that was consistent across all stages of illness and independent of antipsychotic treatment and current cannabis use. This increased tone was [...]

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Au Canada, le cannabis comestible sera disponible à la vente en décembre, Le Monde, 15 juin 2019

Au Canada, le cannabis comestible sera disponible à la vente en décembre Le pays avait été en octobre le deuxième au monde, après l’Uruguay, à autoriser la vente libre de marijuana. Des règles strictes devront être respectées pour limiter l’attractivité des produits à base de cannabis auprès des jeunes. Le Monde avec AFP Publié , 15 juin 2019, aujourd’hui à 00h21, mis à jour à 11h11 Des cookies au cannabis dans un magasin éphèmère de Rome, en Italie, le 6 juin. ANDREW MEDICHINI / AP Des produits comestibles à base de cannabis seront vendus au Canada dès la mi-décembre, a annoncé, [...]

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Cannabis : interdiction au Canada d’en mettre dans la bière, les bonbons et les sucettes, Jean-Yves NAU, juin 2019

Cannabis : interdiction au Canada d’en mettre dans la bière, les bonbons et les sucettes Jean-Yves NAU Blog Journalisme et santé Publique, 15 juin 2019 Bonjour C’était écrit dans la légalisation du cannabis : son industrie du cannabis se professionnalise à grande vitesse 1, élargit sans cesse sa palette. Aujourd’hui l’Agence France Presse nous apprend que des « produits comestibles à base de cannabis » seront vendus au Canada dès la mi-décembre. Annonce officielle faite, vendredi 14 juin, par le gouvernement canadien. Qui précise que les « produits susceptibles de plaire aux enfants » (comme les bonbons ou les sucettes) ne pourront pas en contenir 2. Ces nouvelles dispositions  entreront en vigueur [...]

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Ketamine and Other NMDA Antagonists : Early Clinical Trials and Possible Mechanisms in Depression, D. Jeffrey Newport et al., 2015

Ketamine and Other NMDA Antagonists : Early Clinical Trials and Possible Mechanisms in Depression D. Jeffrey Newport, M.D., M.S., M.Div., Linda L. Carpenter, M.D., William M. McDonald, M.D., James B. Potash, M.D., M.P.H., Mauricio Tohen, M.D., Dr.P.H., M.B.A., Charles B. Nemeroff, M.D., Ph.D., The APA Council of Research Task Force on Novel Biomarkers and Treatments American Journal of Psychiatry, 2015, 172, 950–966 doi: 10.1176/appi.ajp.2015.15040465     Objective : The authors conducted a systematic review and meta-analysis of ketamine and other N-methyl-D-aspartate (NMDA) receptor antagonists in the treatment of major depression. Method : Searches of MEDLINE, PsycINFO, and other databases were conducted for placebo-controlled, double-blind, randomized clinical trials [...]

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Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression. A Randomized Clinical Trial, Ella J. Daly et al., 2019

Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression. A Randomized Clinical Trial Ella J. Daly, MD; Madhukar H. Trivedi, MD; Adam Janik, MD; Honglan Li, MD, PhD; Yun Zhang, PhD; Xiang Li, PhD; Rosanne Lane, MAS; Pilar Lim, PhD; Anna R. Duca, BSN; David Hough, MD; Michael E. Thase, MD; John Zajecka, MD; Andrew Winokur,MD, PhD; Ilona Divacka, MBA, MD; Andrea Fagiolini, MD; Wiesław J. Cubała, MD, PhD; István Bitter,MD, PhD; Pierre Blier,MD, PhD; Richard C. Shelton, MD; Patricio Molero,MD, PhD; Husseini Manji, MD;Wayne C. Drevets, MD; Jaskaran B. Singh, MD JAMA Psychiatry, [...]

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