Cannabinoids : Extraction Methods, Analysis and Physicochemical Characterization Cristina Lujan RAMIREZ, Maria Alejandra FANOVICH, Maria Sandra CHURIO. Studies in Natural Products Chemistry, Chapter 4, 2019, Volume 61, 143-173 (1-44). Doi : 10.1016/B978-0-444-64183-0.00004-X ABSTRACT : A new paradigm has been established in the application of cannabinoids in the last decade. The growing accessibility to different types of Cannabis products and the rise in concern about their health benefits have provoked a rapid expansion of the research interests in phytocannabinoids with promising pharmacological properties. The characterization of the diverse chemotypes of Cannabis sativa, the elucidation of their various structures, and quantification of cannabinoids in the complex [...]
Lire la suiteCancer, Cannabis, and the Search for Relief Marcin Chwistek JNCCN—Journal of the National Comprehensive Cancer Network, 2019, Volume 17, Issue 9, 1142-1144. doi : 10.6004/jnccn.2019.7347 “How about medical marijuana?” is a common and often challenging question in oncology clinics today. It is easy to see why. Answering the question is fraught with clinical, legal, and administrative uncertainties. We all want to give patients the best advice, but not much about medical cannabis seems straightforward today. Whatever answer we provide can feel unsatisfactory to patients or ourselves. Answering clinical questions through high-quality research will take many years. And significant political power will be needed to [...]
Lire la suiteA low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers Johannes G. Ramaekers, Nadia Hutten, Natasha L. Mason, Patrick Dolder1, Eef L. Theunissen, Friederike Holze, Matthias E. Liechti, Amanda Feilding and Kim P.C. Kuypers Journal of Psychopharmacology, 2020, 1–8. doi : 10.1177/026988112094093 Abstract Background : Lysergic acid diethylamide (LSD) is an ergot alkaloid derivative with psychedelic properties that has been implicated in the management of persistent pain. Clinical studies in the 1960s and 1970s have demonstrated profound analgesic effects of full doses of LSD in terminally ill patients, but this line of research evaporated after LSD was scheduled worldwide. Aim : The present [...]
Lire la suiteThe Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer Oliviero Marinelli, Maria Beatrice Morelli, Daniela Annibali, Cristina Aguzzi, Laura Zeppa, Sandra Tuyaerts, Consuelo Amantini, Frédéric Amant, Benedetta Ferretti, Federica Maggi, Giorgio Santoni, Massimo Nabissi International Journal of Molecular Sciences, 2020, 21, 5409 doi : 10.3390/ijms21155409 Abstract : Several studies support, both in vitro and in vivo, the anti-cancer effects of cannabidiol (CBD), a transient receptor potential vanilloid 2 (TRPV2) ligand. TRPV2, often dysregulated in tumors, is associated with altered cell proliferation and aggressiveness. Endometrial cancer (EC) is historically divided in type I endometrioid EC and type II non-endometrioid EC, associated with [...]
Lire la suiteFDA Approves Clinical Trials for Cannabinoid Drug Designed to Reduce COVID Lung Inflammation Ralph Ellis Medscape, August 21, 2020 The US Food and Drug Administration has approved phase one clinical trials for a synthetic cannabinoid drug designed to treat acute respiratory distress syndrome (ARDS), a life-threatening lung condition which may occur in severe cases of the novel coronavirus, Forbes reported. ARDS can be triggered by over-creation of cytokines, proteins which tell the body to produce more inflammation, Forbes said. The drug going to clinical trials, ARDS-003, would “dampen the cytokine release" and prevent development of ARDS, Tetra Bio-Pharma company CEO and chief regulatory officer Guy Chamberland, MD, [...]
Lire la suiteMedicinal use of cannabis based products and cannabinoids Tom P. Freeman, Chandni Hindocha, Sebastian F. Green, Michael A. P. Bloomfield British Medical Journal, 2019, 365, l1141 doi : 10.1136/bmj.l1141 What you need to know • Cannabis based products for medicinal use contain cannabinoids derived from the cannabis plant, including Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), or a combination of THC and CBD. Synthetic cannabinoids for medicinal use typically mimic the effects of specific cannabinoids such as THC • THC is the constituent of cannabis that causes the “high,” whereas CBD is not intoxicating at typical doses. THC and CBD have contrasting mechanisms of action and therapeutic indications; THC [...]
Lire la suiteTRIBUNE. « Après la crise du Covid-19, il faut légaliser le cannabis, vite ! » Emmenés par le député des Bouches-du-Rhône François-Michel Lambert, une soixantaine d’élus de tous bords (LREM, EELV, UDI, LFI, LR) et des médecins estiment que la légalisation du cannabis est une des solutions du monde d’après Covid-19 Par François-Michel Lambert (député et coprésident de LEF), Caroline Janvier (députée LREM), Sylvia Pinel (députée PRG) et Jean-Luc Bennahmias (membre du CESE) Publié le 18 juin 2020 à 07h00 Mis à jour le 18 juin 2020 à 19h31 https://www.nouvelobs.com/societe/20200618.OBS30192/tribune-apres-la-crise-du-covid-19-il-faut-legaliser-le-cannabis-vite.html#modal-msg Photo d’illustration. (ROBYN BECK / AFP) En juin 2019, avec une vingtaine de députés, nous déposions une proposition de [...]
Lire la suiteAdolescent Treatment Admissions for Marijuana Following Recreational Legalization in Colorado and Washington Jeremy Mennis, Gerald J Stahler Drug and Alcohol Dependence, 2020 May 1, 210, 107960. doi : 10.1016/j.drugalcdep.2020.107960 Abstract Introduction : There is concern that recreational marijuana legalization (RML) may lead to increased cannabis use disorder (CUD) among youth due to increased marijuana use. This study investigates whether adolescent substance use disorder treatment admissions for marijuana use increased in Colorado and Washington following RML. Methods : Annual data on 2008-2017 treatment admissions for marijuana use from the SAMHSA TEDS-A dataset for adolescents age 12-17 were used to model state treatment admissions trends. [...]
Lire la suiteIACM-Bulletin du 13 Juin 2020 Science/Israël: Les anciens Israélites ont peut-être consommé du cannabis dans le cadre d'un rituel religieux il y a 3000 ans Science/Homme: Une étude ne trouve aucune preuve que la consommation de cannabis augmente le risque d'AVC Science/Homme: Les données scientifiques disponibles ne supportent pas l'hypothèse selon laquelle la consommation de cannabis peut augmenter l'accident du travail Science/Homme: La consommation de cannabis est associée à une réduction des symptômes chez les patients souffrant de trouble de stress post-traumatique Science/Homme: Selon une étude ouverte le cannabis peut être utile dans le traitement [...]
Lire la suiteAprès la crise du Covid-19 il faut légaliser le cannabis, vite ! François-Michel LAMBERT député des Bouches du Rhône En juin 2019 avec une vingtaine de députés nous déposions une proposition de loi, relative « à la légalisation contrôlée de la production, de la vente et de la consommation de cannabis ». La même semaine le « conseil d’analyse économique », think tank rattaché à Matignon, préconisait dans un rapport très documenté la légalisation du cannabis récréatif et une tribune dans l’Obs signée par 70 médecins, économistes et élus nationaux et locaux, plaidait pour cette légalisation. Ces initiatives pour la légalisation du cannabis dénoncent [...]
Lire la suite