Cannabis use and the course and outcome of major depressive disorder : A population based longitudinal study FEINGOLD D., REHM J., LEV-RAN S. Psychiatry Research, 2017, 251, 225-234. Doi : 10.1016/j.psychres.2017.02.027 Highlights • Individuals with baseline major depressive disorder were followed over a three-year time period. • Cannabis users and individuals with cannabis use disorders were compared to nonusers. • No differences were found in rates of remission between the groups. • Level of cannabis use was associated with significantly more depressive symptoms at follow-up. • These findings did not retain significance after adjusting for baseline confounding factors. Abstract Cannabis use has been reported to affect [...]
Lire la suiteCannabidiol Administered During Peri-Adolescence Prevents Behavioral Abnormalities in an Animal Model of Schizophrenia Fernanda F. Peres, Mariana C. Diana, Raquel Levin, Mayra A. Suiama, Valéria Almeida, Ana M. Vendramini, Camila M. Santos, Antônio W. Zuardi, Jaime E. C. Hallak, José A. Crippa and Vanessa C. Abílio Frontiers in Pharmacology, 2018, 9, article 901. Doi : 10.3389/fphar.2018.00901 Schizophrenia is considered a debilitating neurodevelopmental psychiatric disorder and its pharmacotherapy remains problematic without recent major advances. The development of interventions able to prevent the emergence of schizophrenia would therefore represent an enormous progress. Here, we investigated whether treatment with cannabidiol (CBD – a compound of Cannabis sativa that [...]
Lire la suiteThe origins of cannabis smoking: Chemical residue evidence from the first millennium BCE in the Pamirs Meng Ren, Zihua Tang, Xinhua Wu, Robert Spengler, Hongen Jiang, Yimin Yang, Nicole Boivin Science Advances, 2019, 5, eaaw1391. Doi : 10.1016/sciadv.aaw1391 Cannabis is one of the oldest cultivated plants in East Asia, grown for grain and fiber as well as for recreational, medical, and ritual purposes. It is one of the most widely used psychoactive drugs in the world today, but little is known about its early psychoactive use or when plants under cultivation evolved the phenotypical trait of increased specialized compound production. The archaeological evidence for [...]
Lire la suiteShort-term effects of cannabis consumption on cognitive performance in medical cannabis patients Phillip Olla, Nicholas Rykulski, Jessica L. Hurtubise, Stephen Bartol, Rachel Foote, Laura Cutler, Kaitlyn Abeare, Nora McVinnie, Alana G. Sabelli, Maurissa Hastings, and Laszlo A. Erdodi Applied Neuropsychology : Adult, 2019, 1-11. Doi : 10.1080/23279095.2019.1681424 ABSTRACT This observational study examined the acute cognitive effects of cannabis. We hypothesized that cognitive performance would be negatively affected by acute cannabis intoxication. Twenty-two medical cannabis patients from Southwestern Ontario completed the study. The majority (n¼13) were male. Mean age was 36.0 years, and mean level of education was 13.7 years. Participants were administered the same brief neurocognitive battery three times during [...]
Lire la suiteQuality of Life, Mental Health, Personality and Patterns of Use in Self-Medicated Cannabis Users with Chronic Diseases : A 12-Month Longitudinal Study. BOUSO J.C., JIMENEZ-GARRIDO D., ONA G., WOZNICA D., dos SANTOS R.G., HALLAK J.E.C., PARANHOS B. A., de ALMEIDA MENDES F., YONAMINE M. et al. : Phytotherapy Research, 2020. Doi : 10.1002/ptr.6639 © 2020 John Wiley & Sons, Ltd. Abstract The number of patients using cannabis for therapeutic purposes is growing worldwide. While research regarding the treatment of certain diseases/disorders with cannabis and cannabinoids is also expanding, only a few longitudinal studies have assessed the mid-term impacts of medical cannabis use on psychological variables and quality [...]
Lire la suiteCannabis Use Motivations among Adults Prescribed Opioids for Pain versus Opioid Addiction Selena N. Clem, Teresa L. Bigand, Marian Wilson Pain Management Nursing, 2019, 1-5. Doi : 10.1016/j.pmn.2019.06.009 a b s t r a c t Background : Cannabis has been linked to reduced opioid use, although reasons for cannabis use among adults prescribed opioids are unclear. Aims : The purpose of this study was to determine whether motivations for cannabis use differ between adults prescribed opioids for persistent pain versus those receiving opioids as medication-assisted treatment for opioid use disorder. Design : A cross-sectional survey design was used. Participants : Adults prescribed opioids for persistent pain (n [...]
Lire la suiteBenefits and adverse effects of cannabis use among adults with persistent pain Teresa Bigand, Cristina Lee Anderson, Mary Lee Roberts, Michele Rose Shaw, Marian Wilson Nursing Outlook, 2 0 1 9 , 67, 2 2 3 -2 3 1 doi : 10.1016/j.outlook.2018.12.014. A B S T R A C T Background : Increasingly, states are legalizing cannabis for recreational use. Improved accessibility may allow adults with pain to use cannabis more liberally. Greater understanding is needed about how adults with pain perceive the effects of cannabis, particularly those who also use opioid analgesics. Purpose : To examine the perceived effects of cannabis among adults who have [...]
Lire la suiteOpioid mortality following implementation of medical marijuana programs (1999-2017) in the United States Daniel E. Kaufman, Asawer M. Nihal, Janan D. Leppo, Kelly M. Staples, Kenneth L. McCall, Brian J. Piper BioRxiv preprint, June 14, 2019. Doi : 10.1101/670059 Abstract The United States is in the midst of an opioid overdose epidemic. A prior report using the Center for Disease Control’s Wide-ranging Online Data for Epidemiologic Research (WONDER) database discovered that opioid overdoses decreased by 24.8% from 1999 to 2010 in states with medical cannabis (MC+) relative to those without (MC-). The present study evaluated any differences following MC legislation on WONDER reported opioid overdoses, [...]
Lire la suiteCannabis Use and Cognition in Adults Prescribed Opioids for Persistent Pain Megan Wildes, Teresa L. Bigand, Matthew E. Layton, , Marian Wilson Pain Management Nursing, 2019, 1-6. Doi : 10.1016/j.pmn.2019.06.014 a b s t r a c t Background : Adults with persistent pain frequently report cannabis use to help manage their symptoms. The impact of cannabis use on cognition in the presence of concurrent symptoms of depression and anxiety is poorly understood. Aims : Our study explored how cannabis use affects relationships among symptoms of depression, anxiety, and cognition. Design : A cross-sectional survey study was conducted. Settings : Surveys were distributed at outpatient clinics treating adults [...]
Lire la suiteCannabis Use Moderates the Relationship between Pain and Negative Affect in Adults with Opioid Use Disorder Marian Wilson, Hannah Y. Gogulski, Carrie Cuttler, Teresa L. Bigand, Oladunni Oluwoye,Celestina Barbosa-Leiker, MaryLee A. Roberts Addictive Behaviors, 2017, 30 p. doi : 10.1016/j.addbeh.2017.10.012 Abstract Introduction : Adults in Medication-Assisted Treatment (MAT) for opioid addiction are at risk for substance use relapse and opioid overdose. They often have high rates of cannabis use and comorbid symptoms of pain, depression, and anxiety. Low levels of self-efficacy (confidence that one can self-manage symptoms) are linked to higher symptom burdens and increased substance use. The effects of cannabis use on symptom management [...]
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