Cannabinol inhibits proliferation and induces cell cycle arrest and apoptosis in glioblastoma, hepatocellular carcinoma and breast cancer cells Nuanying ZHONG, Thesis, Master of Science in Biological Sciences Faculty of Arts and Science, Department of Biological Sciences, University of Lethbridge Research Repository, Canada 2020 https://hdl.handle.net/10133/5697 ABSTRACT Cannabis sativa is an agriculturally and medicinally plant with many pharmaceutical properties. Cancer is a deadly disease; it is estimated that it will cause over 80 thousand deaths in 2019 in Canada. Although numerous studies have demonstrated that cannabinoids have anti-tumorous properties in various cancers, the anti-malignant activities of cannabinol (CBN) on carcinogenesis and underlying mechanisms remain largely unknown. In this study, we [...]
Lire la suiteTerpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors David B. Finlay, Kathleen J. Sircombe, Mhairi Nimick, Callum Jones and Michelle Glass Frontiers in Pharmacology, 2020, Volume 11, Article 359, 1-9. doi : 10.3389/fphar.2020.00359 The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other lipids released from cells at the same time. An increasing volume of anecdotal reports and interest in the plant have provoked research into the activity of minor chemical constituents of the plant—including volatile terpenoids such as myrcene, a- and b- pinene, b-caryophyllene, and limonene. However, to [...]
Lire la suiteAppel urgent de la société civile : du cannabis médical pour nos aînés !, signataires, 20 avril 2020
Appel urgent de la société civile : du cannabis médical pour nos aînés ! Nous, associations d’usagers de cannabis à des fins thérapeutiques, médecins et travailleurs sociaux dans le champ des addictions, militants humanitaires appelons solennellement le ministre de la Santé, Olivier Véran, le gouvernement d’Edouard Philippe et le Président de la République, Emmanuel Macron, à rendre possible l’accès immédiat au cannabis à usage médical. Comme l’ont expliqué William Lowenstein et Jean-Yves Nau (Slate du 16 avril 2020), il est choquant que nos anciens reçoivent force benzodiazépines, antidépresseurs, neuroleptiques et opioïdes sans même que l’accès au cannabis à usage thérapeutique soit possible en [...]
Lire la suiteCBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1 Lázaro García-Morales, Aída M Castillo, José Tapia Ramírez, Horacio Zamudio-Meza, Ma del Carmen Domínguez-Robles and Isaura Meza International Journal of Molecular Science, 2020, 21, 2429 doi : 10.3390/ijms21072429 Abstract : Cannabidiol (CBD) has been used to treat a variety of cancers and inflammatory conditions with controversial results. In previous work, we have shown that breast cancer MCF-7 cells, selected by their response to inflammatory IL-1 cytokine, acquire a malignant phenotype (6D cells) through an epithelial mesenchymal transition (EMT).We evaluated CBD as a potential inhibitor of this transition and inducer of [...]
Lire la suiteHigh Times for Painful Blues : The Endocannabinoid System in Pain-Depression Comorbidity Marie Fitzgibbon, David P. Finn, Michelle Roche International Journal of Neuropsychopharmacology, 2016, 19, (3), 1–20 doi : 10.1093/ijnp/pyv095 Abstract Depression and pain are two of the most debilitating disorders worldwide and have an estimate co-occurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability and impaired healthrelated quality of life than either condition alone, resulting in enormous social and economic cost. Several neural substrates have been identified as potential mediators in the association between depression and pain, including neuroanatomical reorganization, monoamine and neurotrophin depletion, dysregulation [...]
Lire la suiteCannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction Guichang Zou, Xin Zuo, Kai Chen, ..., Guangming Huang, Dan Liu, Wei Xiong Cell Reports, 2020, 30, 4209–4219 Doi : 10.1016/j.celrep.2020.02.106 In Brief Zou et al. identify the glycine receptor as a potential therapeutic target for cannabinoids in treating cocaine-induced seizures. The function of extra-synaptic glycine receptors in the prefrontal cortex and hippocampus is impaired by cocaine and rescued by cannabinoids, therefore leading to the therapeutic effects of cannabinoids in treating cocaine-induced seizures. Highlights Cannabinoids alleviate cocaine-induced seizures (CISs) by glycine receptors (GlyRs) Cannabinoid docking reduces hydrogen-bonding interaction between cocaine and GlyRs The prefrontal cortex and hippocampus [...]
Lire la suiteMedical cannabis and insomnia in older adults with chronic pain: a cross-sectional study Sharon R. Sznitman, Simon Vulfsons, David Meiri, Galit Weinstein BMJ Supportive & Palliative Care, 2020, 0, 1–6. doi : 10.1136/bmjspcare-2019-001938 Abstract Objectives : Medical cannabis (MC) is increasingly being used for treatment of chronic pain symptoms. Among patients there is also a growing preference for the use of MC to manage sleep problems. The aim of the current study was to examine the associations between use of whole plant cannabis and sleep problems among chronic pain patients. Methods : A total of 128 individuals with chronic pain over the age of 50 years [...]
Lire la suiteWhat does the ecological and epidemiological evidence indicate about the potential for cannabinoids to reduce opioid use and harms ? A comprehensive review Gabrielle Campbell, Wayne Hall and Suzanne Nielsen International Review of Psychiatry, 2018, 1-16. Doi : 10.1080/09540261.2018.1509842 ABSTRACT Pre-clinical research supports that cannabinoids reduce opioid dose requirements, but few studies have tested this in humans. This review evaluates ecological and epidemiological studies that have been cited as evidence that medical cannabis use may reduce opioid use and opioidrelated harms. Medline and Embase were searched for relevant articles. Data were extracted on study setting, analyses approach, covariates, and outcomes. Eleven ecological and 14 epidemiological [...]
Lire la suiteIl y a urgence à prescrire du cannabis dans les Ehpad Jean-Yves Nau et William Lowenstein — 16 avril 2020 à 10h58 http://www.slate.fr/story/189561/confinement-urgence-prescrire-cannabis-personnes-agees-ehpad Surconfiner les personnes âgées conduit à une consommation désastreuse de benzodiazépines et d'antalgiques opiacés. C'est oublier les vertus alternatives du cannabis médical. La maniabilité de l'administration du cannabis thérapeutique, notamment sous forme de tisanes, est fort intéressante. | Kimzy Nanney via Unsplash Combien, avant l'épidémie, se souciaient des Ehpad, de leurs résident·es, de leurs soignant·es? Combien étions-nous à connaître la signification de cet étrange acronyme, Établissement d'hébergement pour personnes âgées dépendantes? La progression fulgurante du SARS-CoV-2, quelques reportages, de douloureux témoignages, [...]
Lire la suiteConfinement et cannabis, cachez cette addiction que le gouvernement ne saurait voir Jean-Yves Nau — 2 avril 2020 à 7h00 http://www.slate.fr/story/189123/addictions-cannabis-confinement-coronavirus-deni-consequences-dependance Tabac, alcool et produits de vapotage n'ont heureusement pas été interdits. Mais il va falloir compter avec les multiples conséquences de la pénurie en cannabis. «Une dépendance grave à une substance licite vaut toujours mieux qu'une dépendance de moindre gravité à une substance interdite», déplore le Dr William Lowenstein, président de SOS Addictions. | realworkhard, ponce_photography et gjbmiller via Pixabay Il croyait très bien faire. Lundi 23 mars, Ziad Khoury, préfet de l'Aisne, prenait un arrêté interdisant toutes les ventes d'alcool à emporter dans l'ensemble du [...]
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